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Open AccessP01.41. Melittin inhibits VEGF-A-induced tumor growth and angiogenesis through blocking VEGFR-2 and COX-2 in allograft tumor model and endothelial cells
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Open AccessP01.20. The effect of WIN-34B on cartilage protection and regeneration by chondrogenesis from subchondral bone in vitro and in vivo
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Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice
Pancreatic beta cells undergo dynamic remodelling during the perinatal period, with enhanced neogenesis, proliferation and apoptosis observed. The molecular mechanisms responsible for these processes have yet ...
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Article
p53, secreted by K-Ras–Snail pathway, is endocytosed by K-Ras-mutated cells; implication of target-specific drug delivery and early diagnostic marker
p53 is eliminated from K-Ras-mutated cancer cells through direct interaction with Snail. However, it is not achieved through proteasome-mediated degradation or transcriptional repression. Here we provide evide...
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Prohibitin interacts with RNF2 and regulates E2F1 function via dual pathways
Prohibitin, a tumor suppresser protein, plays an important role in the transcriptional regulation of various genes involved in cell-cycle control and proliferation. Recent studies have reported that the growth...
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40th EASD Annual Meeting of the European Association for the Study of Diabetes