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Article
Programming an efficient technique for designing smart C-doped MIC with dual self-protection for information and high-energy
Constructing self-protected metastable intermolecular composites (MICs) enables the regulation of microstructures towards boosting controllable detonation performance, and also prevents information leakage, wh...
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Article
Exogenous melatonin enhanced cadmium stress tolerance of cucumber seedlings (Cucumis sativus L.)
Cadmium (Cd) stress seriously affects cucumber growth, yield, and quality. Melatonin (MT) can enhance plant resistance to abiotic stresses. However, studies on the mechanism of MT in enhancing plant resistance...
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Article
Microwave excited hyperthermy and catalysis of heterostructured Au/Cu–BTA for effective bacteria killing by accelerating charge separation
Deep tissue infections caused by pathogenic bacteria seriously threat the lives of patients. In this study, a smart heterostructured Au/Cu–BTA (BTA = 1,2,4,5-benzenetetramine) with microwave (MW) response is s...
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Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
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Article
Open AccessDynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance
Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.
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Article
Open AccessActivation of GPR81 by lactate drives tumour-induced cachexia
Cachexia affects 50–80% of patients with cancer and accounts for 20% of cancer-related death, but the underlying mechanism driving cachexia remains elusive. Here we show that circulating lactate levels positiv...
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Article
Open AccessStrain-mediated phase crossover in Ruddlesden–Popper nickelates
Recent progress on the signatures of pressure-induced high-temperature superconductivity in Ruddlesden–Popper (RP) nickelates (Lan+1NinO3n+1) has attracted growing interest in both theoretical calculations and ex...
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Article
Open AccessDidymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis
Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most prevalent metabolic syndromes worldwide. However, no approved pharmacological treatments are available for MAFLD. Chenpi, one kin...
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Article
Type 2 Biomarkers for the Indication and Response to Biologics in CRSwNP
Three biologics targeting type 2 inflammation have been approved for the treatment of severe and uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP). Nevertheless, around 40–60% of patients do not r...
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Article
Differentiation between renal epithelioid angiomyolipoma and clear cell renal cell carcinoma using clear cell likelihood score
Clear cell likelihood score (ccLS) may be a reliable diagnostic method for distinguishing renal epithelioid angiomyolipoma (EAML) and clear cell renal cell carcinoma (ccRCC). In this study, we aim to explore t...
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Article
Arranging cation mixing and charge compensation of TiNb2O7 with W6+ do** for high lithium storage performance
TiNb2O7 is an advanced anode material for high-energy density lithium-ion batteries (LIBs) due to its considerable specific capacity and satisfactory safety. However, its rate capability is limited by its poor io...
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Article
Maternal weight, blood lipids, and the offspring weight trajectories during infancy and early childhood in twin pregnancies
The intrauterine environment has a profound and long-lasting influence on the health of the offspring. However, its impact on the postnatal catch-up growth of twin children remains unclarified. Therefore, this...
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Article
Fully automated pixel-wise quantitative CMR-myocardial perfusion with CMR-coronary angiography to detect hemodynamically significant coronary artery disease
We applied a fully automated pixel-wise post-processing framework to evaluate fully quantitative cardiovascular magnetic resonance myocardial perfusion imaging (CMR-MPI). In addition, we aimed to evaluate the ...
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Article
Open AccessEffect of using reclaimed water via furrow and subsurface drip systems under alternate partial root-zone irrigation mechanism on crops growth and soil properties
The growing population in the face of water scarcity inevitably necessitates the quest for alternative sources of irrigation water, which integrates them with irrigation strategies for improved agricultural pr...
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Article
Open AccessChronic cough relief by allosteric modulation of P2X3 without taste disturbance
P2X receptors are cation channels that sense extracellular ATP. Many therapeutic candidates targeting P2X receptors have begun clinical trials or acquired approval for the treatment of refractory chronic cough...
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Article
Geological evaluation for the carbon dioxide geological utilization and storage (CGUS) site: A review
Carbon dioxide (CO2) geological utilization and storage (CGUS) is the key link of CO2 capture, utilization, and storage (CCUS). The accurate characterization of the geological body structure is a vital prerequisi...
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Article
Measurement of the 232Th(n,f) cross section in the 1–200 MeV range at the CSNS Back-n
The 232Th(n,f) cross section is very important in basic nuclear physics and applications based on the Th/U fuel cycle. Using the time-of-flight method and a multi-cell fast-fission ionization chamber, a novel mea...
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Article
Open AccessA 71-year-old male with a life-threatening recurrence of hemolytic anemia, thrombocytopenia, and acute kidney injury after pembrolizumab therapy: a case report
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, their use has been restricted in patients with preexisting autoimmune diseases due to concerns about increased risk of immune-...
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Article
Open AccessNegative associations between folate and bacterial vaginosis in the NHANES 2001 to 2004
Bacterial vaginosis (BV) is one of the most common infections among women of reproductive age and accounts for 15–50% of infections globally. The role played by folate in the pathogenesis and progression of BV...
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Article
The tumor immune microenvironment of nasopharyngeal carcinoma after gemcitabine plus cisplatin treatment
Gemcitabine plus cisplatin (GP) chemotherapy is the standard of care for nasopharyngeal carcinoma (NPC). However, the mechanisms underpinning its clinical activity are unclear. Here, using single-cell RNA sequ...
