75 Result(s)

Article

Landform and lithospheric development contribute to the assembly of mountain floras in China

Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...

Wan-Yi Zhao, Zhong-Cheng Liu, Shi Shi, Jie-Lan Li, Ke-Wang Xu… in Nature Communications (2024)

Article

Dynamic genomic changes in methotrexate-resistant human cancer cell lines beyond DHFR amplification suggest potential new targets for preventing drug resistance

Although DHFR gene amplification has long been known as a major mechanism for methotrexate (MTX) resistance in cancer, the early changes and detailed development of the resistance are not yet fully understood.

**ang-Ning Meng, **-Fa Ma, Yang-He Liu, Si-Qing Li, Xu Wang… in British Journal of Cancer (2024)

Article

Activation of GPR81 by lactate drives tumour-induced cachexia

Cachexia affects 50–80% of patients with cancer and accounts for 20% of cancer-related death, but the underlying mechanism driving cachexia remains elusive. Here we show that circulating lactate levels positiv...

**dan Liu, Shi** Li, Qionghua Cui, Bu**g Guo, Wanqiu Ding, Jie Liu… in Nature Metabolism (2024)

Article

Strain-mediated phase crossover in Ruddlesden–Popper nickelates

Recent progress on the signatures of pressure-induced high-temperature superconductivity in Ruddlesden–Popper (RP) nickelates (La_n+1Ni_nO_3n+1) has attracted growing interest in both theoretical calculations and ex...

Ting Cui, Songhee Choi, Ting Lin, Chen Liu, Gang Wang… in Communications Materials (2024)

Article

Didymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis

Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most prevalent metabolic syndromes worldwide. However, no approved pharmacological treatments are available for MAFLD. Chenpi, one kin...

**g-wen Yang, Ying Zou, Jun Chen, Chen Cui, Jia Song… in Journal of Translational Medicine (2023)

Article

Effect of using reclaimed water via furrow and subsurface drip systems under alternate partial root-zone irrigation mechanism on crops growth and soil properties

The growing population in the face of water scarcity inevitably necessitates the quest for alternative sources of irrigation water, which integrates them with irrigation strategies for improved agricultural pr...

Mahmoud S. Hashem, Wei Guo, Xue-Bin Qi, ** Li, Ying-jun She… in Irrigation Science (2023)

Article

Chronic cough relief by allosteric modulation of P2X3 without taste disturbance

P2X receptors are cation channels that sense extracellular ATP. Many therapeutic candidates targeting P2X receptors have begun clinical trials or acquired approval for the treatment of refractory chronic cough...

Chang-Run Guo, Zhong-Zhe Zhang, **ng Zhou, Meng-Yang Sun… in Nature Communications (2023)

Article

A 71-year-old male with a life-threatening recurrence of hemolytic anemia, thrombocytopenia, and acute kidney injury after pembrolizumab therapy: a case report

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. However, their use has been restricted in patients with preexisting autoimmune diseases due to concerns about increased risk of immune-...

**n Zhang, Bi-xia Gao, Cui-yan Guo, Tao Su in BMC Geriatrics (2023)

Article

Negative associations between folate and bacterial vaginosis in the NHANES 2001 to 2004

Bacterial vaginosis (BV) is one of the most common infections among women of reproductive age and accounts for 15–50% of infections globally. The role played by folate in the pathogenesis and progression of BV...

Ting-Ting Cui, **g Luo, Rui-Lan Deng, Yun-Ting Yang, Ya-Wen Yin… in BMC Infectious Diseases (2023)

Article

Identification of three elevenin receptors and roles of elevenin disulfide bond and residues in receptor activation in Aplysia californica

Neuropeptides are ubiquitous intercellular signaling molecules in the CNS and play diverse roles in modulating physiological functions by acting on specific G-protein coupled receptors (GPCRs). Among them, the...

** Fu, Yu-Shuo Mei, Wei‑Jia Liu, ** Chen, Qing-Chun **… in Scientific Reports (2023)

Article

First application of plutonium in soil erosion research on terraces

The spatial distributions of ^239+240Pu and ¹³⁷Cs in soils from Longji Rice Terraces were investigated to evaluate soil erosion. The activity concentrations of ^239+240Pu and ¹³⁷Cs in the surface soils of the paddy...

Yong-**g Guan, Wu Chen, Shen-Zhen Wang, Yu-**n Hua… in Nuclear Science and Techniques (2023)

Article

Head-to-head comparison of 6 plasma biomarkers in early multiple system atrophy

There is a dire need for reliable biomarkers to solidify an early and accurate diagnosis of multiple system atrophy (MSA). We sought to compare the ability of emerging plasma markers in distinguishing MSA from...

Yu Guo, Xue-Ning Shen, Shu-Yi Huang, Shu-Fen Chen, Hui-Fu Wang… in npj Parkinson's Disease (2023)

Article

The dynamics of plasma biomarkers across the Alzheimer’s continuum

Failures in drug trials strengthen the necessity to further determine the neuropathological events during the development of Alzheimer’s disease (AD). We sought to investigate the dynamic changes and performan...

Yu Guo, Xue-Ning Shen, Hui-Fu Wang, Shi-Dong Chen… in Alzheimer's Research & Therapy (2023)

Article

Stigma receptors control intraspecies and interspecies barriers in Brassicaceae

Flowering plants have evolved numerous intraspecific and interspecific prezygotic reproductive barriers to prevent production of unfavourable offspring¹. Within a species, self-incompatibility (SI) is a widely ut...

Jiabao Huang, Lin Yang, Liu Yang, **aoyu Wu, **aoshuang Cui, Lili Zhang… in Nature (2023)

Article

Correction: Human brucellosis and fever of unknown origin

Zhi-guo Wu, Zhi-ying Song, Wei-xin Wang, Wen-na **, Di **… in BMC Infectious Diseases (2023)

Article

Loss of function of CMPK2 causes mitochondria deficiency and brain calcification

Brain calcification is a critical aging-associated pathology and can cause multifaceted neurological symptoms. Cerebral phosphate homeostasis dysregulation, blood-brain barrier defects, and immune dysregulatio...

Miao Zhao, Hui-Zhen Su, Yi-Heng Zeng, Yuan Sun, **n-**n Guo, Yun-Lu Li… in Cell Discovery (2022)

Article

Human brucellosis and fever of unknown origin

Human brucellosis has become one of the major public health problems in China, and increases atypical manifestations, such as fever of unknown origin (FUO), and misdiagnosis rates has complicated the diagnosis...

Zhi-guo Wu, Zhi-ying Song, Wei-xin Wang, Wen-na **, Di **… in BMC Infectious Diseases (2022)

Article

Investigation of urine metabolome of BALB/c mouse infected with an avirulent strain of Toxoplasma gondii

The protozoan parasite Toxoplasma gondii is a major concern for human and animal health. Although the metabolic understanding of toxoplasmosis has increased in recent years, the analysis of metabolic alterations ...

Chun-Xue Zhou, Ling-Yu Li, Cui-Qin Huang, Xu-Dong Guo, Xu-Dian An… in Parasites & Vectors (2022)

Article

Author Correction: CDER167, a dual inhibitor of URAT1 and GLUT9, is a novel and potent uricosuric candidate for the treatment of hyperuricemia

Ze-an Zhao, Yu Jiang, Yan-yu Chen, Ting Wu, Qun-sheng Lan… in Acta Pharmacologica Sinica (2022)

Article

Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder

The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsiste...

Yu-Dan Ding, **ao Chen, Zuo-Bing Chen, Le Li, Xue-Ying Li… in Translational Psychiatry (2022)