19 Result(s)
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Open AccessDidymin alleviates metabolic dysfunction-associated fatty liver disease (MAFLD) via the stimulation of Sirt1-mediated lipophagy and mitochondrial biogenesis
Metabolic dysfunction-associated fatty liver disease (MAFLD) is one of the most prevalent metabolic syndromes worldwide. However, no approved pharmacological treatments are available for MAFLD. Chenpi, one kin...
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Inactivation of ERK1/2-CREB Pathway Is Implicated in MK801-induced Cognitive Impairment
Schizophrenia (SZ) is associated with cognitive impairment, and it is known that the activity of cAMP response element binding protein (CREB) decreases in the brain of SZ patients. The previous study conducted...
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Open AccessReduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder
The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsiste...
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Open AccessSORBS2 as a molecular target for atherosclerosis in patients with familial hypercholesterolemia
Familial hypercholesterolemia (FH) is a metabolic disease in which patients are prone to develop premature atherosclerosis (AS). Sorbin and SH3 Domain Containing 2 (SORBS2) is known to play a role in coronary ...
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Open AccessInflammation and atherosclerosis: signaling pathways and therapeutic intervention
Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstra...
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Article
Open AccessCD147 supports paclitaxel resistance via interacting with RanBP1
Though the great success of paclitaxel, the variable response of patients to the drug limits its clinical utility and the precise mechanisms underlying the variable response to paclitaxel remain largely unknow...
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Open AccessDisrupted intrinsic functional brain topology in patients with major depressive disorder
Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, w...
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Open AccessCD147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression
Major gaps in understanding the molecular mechanisms of colorectal cancer (CRC) progression and intestinal mucosal repair have hampered therapeutic development for gastrointestinal disorders. Trefoil factor 3 ...
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Article
Cornel Iridoid Glycoside Regulates Modification of Tau and Alleviates Synaptic Abnormalities in Aged P301S Mice
Alzheimer’s disease (AD), also defined as a tauopathology, is a common neurodegenerative disease. Hyper-phosphorylation, cleavage or truncation, and aggregation of tau contribute to AD. Thus, targeting the pos...
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Open AccessPrognostic utility of lipoprotein(a) combined with fibrinogen in patients with stable coronary artery disease: a prospective, large cohort study
Elevated lipoprotein(a) [Lp(a)] and fibrinogen (Fib) are both associated with coronary artery disease (CAD). The atherogenicity of Lp(a) can be partly due to the potentially antifibrinolytic categories. We hyp...
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Open AccessPretreatment quality of life as a predictor of survival for patients with nasopharyngeal carcinoma treated with IMRT
To evaluate the prognostic significance of pretreatment quality of life for patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy.
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Article
Changes in endolymphatic hydrops visualized by magnetic resonance imaging after sac surgery
The purpose of the study was to observe changes in endolymphatic hydrops by using intratympanic injection of gadolinium and magnetic resonance imaging (MRI) before and after endolymphatic sac surgery in patien...
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Open AccessPrevalence and characterization of hepatitis B and C virus infections in a needle-sharing population in Northern China
The epidemiologies of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in specific populations in certain areas of China are poorly understood. A pilot survey of HCV/HBV infections was carried ou...
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Article
Urine flow acceleration is superior to Qmax in diagnosing BOO in patients with BPH
We performed a retrospective, case-control study to evaluate whether the urine flow acceleration (UFA, mL/s2) is superior to maximum uroflow (Qmax, mL/s) in diagnosing bladder outlet obstruction (BOO) in patients...
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Open AccessLow BRMS1 expression promotes nasopharyngeal carcinoma metastasis in vitro and in vivo and is associated with poor patient survival
Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene. This study aimed to investigate the impact of BRMS1 on metastasis in nasopharyngeal carcinoma (NPC) and to evaluate the prognostic...
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Article
Hepatitis B virus X protein up-regulates TNF-α and IL-β secretion of macrophages
To provide the experimental basis for further studying the molecular transformation mechanism of Hepatitis B virus (HBV) X protein (HBx) on hepatocellular carcinoma.
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Article
Effects of puerarin on plasma endothelin and serum tumor necrosis Factor-α in type 2 diabetes mellitus patients with vascular complications
To study the changes of endothelin (ET), tumor necrosis factor-α (TNF-a) before and after puerarin treatment in patients with diabetes mellitus vascular complications (DMVC).
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Article
Clinical study of **maitong composita ( )on diabetic peripheral neuropathy)on diabetic peripheral neuropathy
Objective: To verify the effect of **maitong composita (JMTC) on red blood cell aldose reductase activity (RBC-AR), red blood cell sorbitol (RBC-S) and nerve conductive velocity in diabetic peri...
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The active constituents ofTripterygium wilfordii and their pharmacological actions and clinical application
