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Open AccessAuthor Correction: Coixendide efficacy in combination with temozolomide in glioblastoma and transcriptome analysis of the mechanism
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Open AccessCoixendide efficacy in combination with temozolomide in glioblastoma and transcriptome analysis of the mechanism
The purpose of this study was to explore the role of coixendide (Coix) combine with temozolomide (TMZ) in the treatment of Glioblastoma (GBM) and explore its possible mechanism. CCK-8 was used to determine the...
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Open AccessCase study of a landslide continuous probability rainfall threshold analysis based on the prediction interval principle
Bazhong City is located on stratum dominated by red-bed conditions. This type of weak geological condition with sand and mudstone interbedding is very easily affected by climatic conditions to produce rainfall...
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Open AccessReconstructing spatial pattern of historical cropland in karst areas of Guizhou, Southwest China
Karst regions are exceptionally responsive to global change with their harsh natural environment, fragile ecology, and acute human-land conflicts. The reconstruction of cropland spatial pattern in karst areas ...
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Open AccessModulation of MagR magnetic properties via iron–sulfur cluster binding
Iron–sulfur clusters are essential cofactors found in all kingdoms of life and play essential roles in fundamental processes, including but not limited to respiration, photosynthesis, and nitrogen fixation. Th...
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Open AccessGenetic variations in catechol-O-methyltransferase gene are associated with levodopa response variability in Chinese patients with Parkinson’s disease
Catechol-O-methyltransferase (COMT) is one of the main enzymes in dopamine metabolism and is reported to be associated with susceptibility to Parkinson’s disease (PD) and pharmacotherapy. However, researchers ...
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Open AccessFurther evidence for “gain-of-function” mechanism of DFNA5 related hearing loss
To report two DFNA5 pathogenic splice-site variations and a novel benign frameshift variation to further support the gain-of-function mechanism of DFNA5 related hearing impairment, targeted genes capture and next...
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Open AccessA bony-crested Jurassic dinosaur with evidence of iridescent plumage highlights complexity in early paravian evolution
The Jurassic Yanliao theropods have offered rare glimpses of the early paravian evolution and particularly of bird origins, but, with the exception of the bizarre scansoriopterygids, they have shown similar sk...
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Open AccessActivation of autophagy attenuates EtOH-LPS-induced hepatic steatosis and injury through MD2 associated TLR4 signaling
Autophagy serves as a protective mechanism to degrade damaged organelles and proteins. Acute alcohol exposure is known to activate the hepatic autophagy response, whereas chronic alcohol exposure slows autopha...
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Open AccessOesophageal carcinoma: comparison of ex vivo high-resolution 3.0 T MR imaging with histopathological findings
High-resolution magnetic resonance (MR) images clearly depict the normal oesophageal wall as consisting of eight layers, which correlates well with histopathological findings. In 56 (91.8%) of 61 lesions, the ...
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Open AccessFibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury
Fibroblast growth factor 21 (FGF21) is a hepatokine that regulates glucose and lipid metabolism in the liver. We sought to determine the role of FGF21 in hepatic steatosis in mice exposed to chronic alcohol tr...
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Open AccessUltrahigh capacitive performance from both Co(OH)2/graphene electrode and K3Fe(CN)6 electrolyte
Pseudocapacitance is commonly associated to the reversible redox reactions from electrode materials, but the enhancement in pseudocapacitance that only relies on electrode materials is limited. Here, we explor...
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Open AccessSource rupture process of Lushan M S7.0 earthquake, Sichuan, China and its tectonic implications
The source rupture process of the M S7.0 Lushan earthquake was here evaluated using 40 long-period P waveforms with even azimuth coverage of stations. Results reveal that the rupture process of th...
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An AP SoC for a unified architecture
An instruction level parallel computing paradigm and a unified architecture for an array processor (AP) on a chip (SoC) are presented in this paper. Here “APU SoC” is short for “an AP SoC for the unified archi...
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Rupture process of the Wenchuan M8.0 earthquake of Sichuan China: the segmentation feature
Moment tensor solution, rupture process and rupture characteristics of the great Wenchuan 8.0 earthquake are studied by using 39 long-period P and SH waveforms with evenly azimuth coverage of stations. Our res...