9 Result(s)
within
Crispin T. Hiley
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAuthor Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx
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Open AccessDeep cell phenoty** and spatial analysis of multiplexed imaging with TRACERx-PHLEX
The growing scale and dimensionality of multiplexed imaging require reproducible and comprehensive yet user-friendly computational pipelines. TRACERx-PHLEX performs deep learning-based cell segmentation (deep-...
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Open AccessMixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling
The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor...
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Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA
Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells persisting after curative intent therapy1. The study of large patient cohorts incorporating longitudinal plasma sampling and ...
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Open AccessThe evolution of non-small cell lung cancer metastases in TRACERx
Metastatic disease is responsible for the majority of cancer-related deaths1. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited pa...
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Open AccessThe evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer...
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Open AccessAntibodies against endogenous retroviruses promote lung cancer immunotherapy
B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS)1,2. Although TLS have been found to correlate with improved...
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Using DNA sequencing data to quantify T cell fraction and therapy response
The immune microenvironment influences tumour evolution and can be both prognostic and predict response to immunotherapy1,2. However, measurements of tumour infiltrating lymphocytes (TILs) are limited by a shorta...
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Neoantigen-directed immune escape in lung cancer evolution
The interplay between an evolving cancer and a dynamic immune microenvironment remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell lung cancers using RNA sequencing and h...
