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Structural variants shape driver combinations and outcomes in pediatric high-grade glioma

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    Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

    BET-bromodomain inhibition (BETi) has shown pre-clinical promise for MYC-amplified medulloblastoma. However, the mechanisms for its action, and ultimately for resistance, have not been fully defined. Here, usi...

    Pratiti Bandopadhayay, Federica Piccioni, Ryan O’Rourke… in Nature Communications (2019)

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