Skip to main content

3 Result(s)

within Claire Sinai Remove this filter English Remove this filter

and

  1. No Access

    Article

    Structural variants shape driver combinations and outcomes in pediatric high-grade glioma

    We analyzed the contributions of structural variants (SVs) to gliomagenesis across 179 pediatric high-grade gliomas (pHGGs). The most recurrent SVs targeted MYC isoforms and receptor tyrosine kinases (RTKs), incl...

    Frank P. B. Dubois, Ofer Shapira, Noah F. Greenwald, Travis Zack… in Nature Cancer (2022)

  2. Article

    Open Access

    Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma

    BET-bromodomain inhibition (BETi) has shown pre-clinical promise for MYC-amplified medulloblastoma. However, the mechanisms for its action, and ultimately for resistance, have not been fully defined. Here, usi...

    Pratiti Bandopadhayay, Federica Piccioni, Ryan O’Rourke… in Nature Communications (2019)

    Download PDF (1860 KB) View Article

  3. No Access

    Article

    Immunophenoty** of pediatric brain tumors: correlating immune infiltrate with histology, mutational load, and survival and assessing clonal T cell response

    There is little known regarding the immune infiltrate present in pediatric brain tumors and how this compares to what is known about histologically similar adult tumors and its correlation with survival. Here,...

    Ashley S. Plant, Shohei Koyama, Claire Sinai, Isaac H. Solomon… in Journal of Neuro-Oncology (2018)