6 Result(s)
within
Chunyan Ji
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Open AccessCuproptosis-related lncRNA signature as a prognostic tool and therapeutic target in diffuse large B cell lymphoma
Cuproptosis is a newly defined form of programmed cell death that relies on mitochondria respiration. Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis and metastasis. However, whether cupropto...
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Article
Open AccessHomodimer-mediated phosphorylation of C/EBPα-p42 S16 modulates acute myeloid leukaemia differentiation through liquid-liquid phase separation
CCAAT/enhancer binding protein α (C/EBPα) regulates myeloid differentiation, and its dysregulation contributes to acute myeloid leukaemia (AML) progress. Clarifying its functional implementation mechanism is o...
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Article
Open AccessNCBP1 enhanced proliferation of DLBCL cells via METTL3-mediated m6A modification of c-Myc
Diffuse large B-cell lymphoma (DLBCL) is malignant hyperplasia of B lymphocytes and standard care cannot satisfactorily meet clinical needs. Potential diagnostic and prognostic DLBCL biomarkers are needed. NCB...
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Article
Open AccessGut microbiota regulates acute myeloid leukaemia via alteration of intestinal barrier function mediated by butyrate
The gut microbiota has been linked to many cancers, yet its role in acute myeloid leukaemia (AML) progression remains unclear. Here, we show decreased diversity in the gut microbiota of AML patients or murine ...
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Article
Open AccessAnalysis of TET2 and EZH2 gene functions in chromosome instability in acute myeloid leukemia
TET2 and EZH2 play important roles in the epigenetic regulation in many cancers. However, their specific roles in acute myeloid leukemia (AML) pathogenesis remain unknown. Here, the expression, methylation or ...
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Article
Open AccessIncreased expression of surface CD44 in hypoxia-DCs skews helper T cells toward a Th2 polarization
A low partial oxygen pressure (hypoxia) occurs in many pathological environments, such as solid tumors and inflammatory lesions. Understanding the cellular response to hypoxic stress has broad implications for...
