9 Result(s)

Article

Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection

We investigated the crystal structure of an HLA-A*2402-restricted CTL epitope in the HIV-1 nef gene (Nef134-10) before (pHLA) or after TCR docking. The wild type epitope and two escape mutants were included in th...

Akihisa Shimizu, Ai Kawana-Tachikawa, Atsushi Yamagata, Chungyong Han… in Scientific Reports (2013)

Article

Switching and emergence of CTL epitopes in HIV-1 infection

Human Leukocyte Antigen (HLA) class I restricted Cytotoxic T Lymphocytes (CTLs) exert substantial evolutionary pressure on HIV-1, as evidenced by the reproducible selection of HLA-restricted immune escape muta...

Chungyong Han, Ai Kawana-Tachikawa, Akihisa Shimizu, Dayong Zhu… in Retrovirology (2014)

Article

Selective killing of malignant B cells using T cells redirected against malignancy variant receptor

Chungyong Han, Sujung Sim, Kwang Hui Kim… in Journal for ImmunoTherapy of Cancer (2014)

Article

Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression

Chimeric antigen receptor (CAR) T cell therapy is an effective method for treating specific cancers. CARs are normally designed to recognize antigens, which are highly expressed on malignant cells but not on T...

Chungyong Han, Su-Jung Sim, Seon-Hee Kim, Rohit Singh… in Nature Communications (2018)

Article

Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8⁺ T cell responses

The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor immunotherapy. However, the adverse side effects associated with agonist antibodies have hindered their cli...

Seon-Hee Kim, Rohit Singh, Chungyong Han, Eunjung Cho… in Cellular & Molecular Immunology (2021)

Article

Adoptive immunotherapy with transient anti-CD4 treatment enhances anti-tumor response by increasing IL-18Rα^hi CD8⁺ T cells

Adoptive T cell therapy (ACT) requires lymphodepletion preconditioning to eliminate immune-suppressive elements and enable efficient engraftment of adoptively transferred tumor-reactive T cells. As anti-CD4 mo...

Seon-Hee Kim, Eunjung Cho, Yu I. Kim, Chungyong Han, Beom K. Choi… in Nature Communications (2021)

Article

4-1BB-4-1BBL cis-interaction contributes to the survival of self-reactive CD8⁺ T cell

Eunjung Cho, Rohit Singh, Chungyong Han, Seon-Hee Kim… in Cellular & Molecular Immunology (2023)