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Open AccessStudy on the failure mechanism of high-temperature granite under two cooling modes
In the geothermal development of hot dry rock (HDR), both the drilling of the wellbore and the heat exchange of the heat reservoir involve the effects of different cold and hot conditions on the high-temperatu...
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Article
Open AccessRobust pose estimation which guarantees positive depths
In the area of 3D computer vision, the ability to estimate pose between two cameras under high noise levels while maintaining small reprojection errors reflects the robustness of such pose estimation algorithm...
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Article
Open AccessPerformance boost for bismuth telluride thermoelectric generator via barrier layer based on low Young’s modulus and particle sliding
The lack of desirable diffusion barrier layers currently prohibits the long-term stable service of bismuth telluride thermoelectric devices in low-grade waste heat recovery. Here we propose a new design princi...
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Open AccessOn-body non-invasive glucose monitoring sensor based on high figure of merit (FoM) surface plasmonic microwave resonator
High-figure of merit (FoM) plasmonic microwave resonator is researched as a non-invasive on-body sensor to monitor the human body's blood glucose variation rate in adults for biomedical applications, e.g., dia...
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Open AccessA polycistronic system for multiplexed and precalibrated expression of multigene pathways in fungi
Synthetic biology requires efficient systems that support the well-coordinated co-expression of multiple genes. Here, we discover a 9-bp nucleotide sequence that enables efficient polycistronic gene expression...
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Open AccessPrevalence, risk factors, and prognosis of central nervous system manifestations in antiphospholipid syndrome
The central nervous system (CNS) is considered as one of the most frequently affected organs in antiphospholipid syndrome (APS). This study investigated the prevalence of CNS manifestations in APS and associat...
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Open AccessPotassium-rich mining waste addition can shorten the composting period by increasing the abundance of thermophilic bacteria during high-temperature periods
Conventional compost sludge has a long fermentation period and is not nutrient rich. Potassium-rich mining waste was used as an additive for aerobic composting of activated sludge to make a new sludge product....
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Open AccessA new long-snouted marine reptile from the Middle Triassic of China illuminates pachypleurosauroid evolution
Sauropterygia is the largest, most successful group of Mesozoic marine diapsids, spanning from the late Early Triassic to the Late Cretaceous. Plesiomorphic for sauropterygians, pachypleurosauroids are importa...
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Open AccessAssessment of a three-axis on-rotor sensing performance for machining process monitoring: a case study
Online monitoring of cutting conditions is essential in intelligent manufacturing, and vibrations are one of the most effective signals in monitoring machining conditions. Generally, traditional wired accelero...
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Article
Open AccessSuperelastic graphene aerogel-based metamaterials
Ultralight, ultrastrong, and supertough graphene aerogel metamaterials combining with multi-functionalities are promising for future military and domestic applications. However, the unsatisfactory mechanical p...
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Article
Open AccessLow-dose metformin targets the lysosomal AMPK pathway through PEN2
Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects1–4. For clinical doses of metformin, AMP-activated protein kinase (AMPK) has a major role ...
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Evidence for the association of triatomic molecules in ultracold 23Na40K + 40K mixtures
Ultracold assembly of diatomic molecules has enabled great advances in controlled chemistry, ultracold chemical physics and quantum simulation with molecules1–3. Extending the ultracold association to triatomic m...
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Open AccessVitamin D suppresses bleomycin-induced pulmonary fibrosis by targeting the local renin–angiotensin system in the lung
Idiopathic pulmonary fibrosis (IPF) is a severe disorder leading to progressive and irreversible loss of pulmonary function. In this study we investigated the anti-fibrotic effect of vitamin D using a mouse mo...
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Open AccessTopographical map** of the mechanical characteristics of the human neurocranium considering the role of individual layers
The site-dependent load-deformation behavior of the human neurocranium and the load dissipation within the three-layered composite is not well understood. This study mechanically investigated 257 human frontal...
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Open AccessPathway engineering in yeast for synthesizing the complex polyketide bikaverin
Fungal polyketides display remarkable structural diversity and bioactivity, and therefore the biosynthesis and engineering of this large class of molecules is therapeutically significant. Here, we successfully...
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Article
Open AccessDeterministic culturing of single cells in 3D
Models using 3D cell culture techniques are increasingly accepted as the most biofidelic in vitro representations of tissues for research. These models are generated using biomatrices and bulk populations of c...
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Open AccessInfluence of Chronic Ethanol Consumption on Apoptosis and Autophagy Following Transient Focal Cerebral Ischemia in Male Mice
Stroke remains one of the leading causes of permanent disability and death worldwide. Apoptosis and autophagy are two key elements involved in ischemic brain damage. Ethanol is a commonly used and abused chemi...
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Open AccessAntiviral activity of iridoid glycosides extracted from Fructus Gardeniae against influenza A virus by PACT-dependent suppression of viral RNA replication
Epidemic and pandemic influenza A virus (IAV) poses a significant threat to human populations worldwide. Iridoid glycosides are principal bioactive components from the Gardenia jasminoides J. Ellis fruit that exh...
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Open AccessTargeting Forward and Reverse EphB4/EFNB2 Signaling by a Peptide with Dual Functions
The tyrosine kinase receptor EphB4 is frequently overexpressed in ovarian and other solid tumors and is involved in interactions between tumor cells and the tumor microenvironment, contributing to metastasis. ...
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Open AccessPaeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p
Sepsis is a life-threatening disease caused by infection. Inflammation is a key pathogenic process in sepsis. Paeonol, an active ingredient in moutan cortex (a Chinese herb), has many pharmacological activitie...