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Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models

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  1. Article

    Open Access

    Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells

    Immunosuppression by the tumor microenvironment is a pivotal factor contributing to tumor progression and immunotherapy resistance. Priming the tumor immune microenvironment (TIME) has emerged as a promising s...

    Jia-zheng Jiao, Yang Zhang, Wen-juan Zhang, Min-di He in Acta Pharmacologica Sinica (2024)

  2. Article

    Open Access

    Six New 3,5-Dimethylcoumarins from Chelonopsis praecox, Chelonopsis odontochila and Chelonopsis pseudobracteata

    Ten 3,5-dimethylcoumarins (16 and 811) involving six new ones (16), together with a known 3-methylcoumarin (7), were isolated from the aerial parts of three Chelonopsis plants, C. praecox, C. odontochila, and

    Chang-An Geng, Zhen-Tao Deng, Qian Huang in Natural Products and Bioprospecting (2021)

  3. Article

    Open Access

    Protective Effects of Salidroside on Epirubicin-Induced Early Left Ventricular Regional Systolic Dysfunction in Patients with Breast Cancer

    Salidroside [2-(4-hydroxyphenyl)ethyl-β-D-glucopyranoside], one of the most potent ingredients extracted from the plant Rhodiola rosea L., has been shown to have a cardiovascular protective effect as an antioxida...

    Hua Zhang, Wei-sheng Shen, Dr. Chun-heng Gao, Li-chun Deng, Dong Shen in Drugs in R&D (2012)

  4. Article

    Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cell LNCaP

    To elucidate the effect and the mechanisms of curcumin on the expression of the human homeobox gene NKX3.1 in the prostate cancer cell LNCaP.

    Hui-na Zhang, Chun-xiao Yu, Peng-ju Zhang, Wei-wen Chen in Acta Pharmacologica Sinica (2007)

  5. Article

    Multiple dose pharmacokinetics of risperidone and 9-hydroxyrisperidone in Chinese female patients with schizophrenia

    To study the multiple dose clinical pharmacokinetics of risperidone and its main active metabolite, 9-hydroxyrisperidone, in Chinese female patients with schizophrenia.

    Zhi-ling Zhou, **n Li, Huai-yan Peng, **-yong Yu, Ming Yang in Acta Pharmacologica Sinica (2006)