23 Result(s)

Article

Serotonin Transporter (SLC6A4) and FK506-Binding Protein 5 (FKBP5) Genotype and Methylation Relationships with Response to Meditation in Veterans with PTSD

Meditation-based interventions are novel and effective non-pharmacologic treatments for veterans with PTSD. We examined relationships between treatment response, early life trauma exposure, DNA polymorphisms, ...

Adam Lee, Paul Thuras, Joshua Baller, Chuan Jiao, Bin Guo… in Molecular Neurobiology (2024)

Article

Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial

The combination of immune-checkpoint blockade with chemotherapy for the first-line treatment of advanced triple-negative breast cancer (TNBC) has generated mixed results. TORCHLIGHT is a randomized, double-bli...

Zefei Jiang, Quchang Ouyang, Tao Sun, Qingyuan Zhang, Yuee Teng… in Nature Medicine (2024)

Article

Dual Effects of Light on Regulating Aedes aegypti Heat-Seeking Behavior

Haonan Zhou, Kai Shi, Fengming Wu, Bingcai Wang, **g Li… in Neuroscience Bulletin (2022)

Article

Fibroblast Growth Factor 9 Stimulates Neuronal Length Through NF-kB Signaling in Striatal Cell Huntington’s Disease Models

Proper development of neuronal cells is important for brain functions, and impairment of neuronal development may lead to neuronal disorders, implying that improvement in neuronal development may be a therapeu...

Issa Olakunle Yusuf, Hsiu-Mei Chen, Pei-Hsun Cheng, Chih-Yi Chang… in Molecular Neurobiology (2021)

Article

A Point Mutation in SCN1A 5′ Genomic Region Decreases the Promoter Activity and Is Associated with Mild Epilepsy and Seizure Aggravation Induced by Antiepileptic Drug

The SCN1A gene with 1274 point mutations in the coding regions or genomic rearrangements is the most clinically relevant epilepsy gene. Recent studies have demonstrated that variations in the noncoding regions ar...

Qu-Wen Gao, Li-Dong Hua, Jie Wang, Cui-**a Fan, Wei-Yi Deng… in Molecular Neurobiology (2017)

Article

Elevated Serum Levels of CXC Chemokine Ligand-12 Are Associated with Unfavorable Functional Outcome and Mortality at 6-Month Follow-up in Chinese Patients with Acute Ischemic Stroke

The aim of this study was to examine whether the circulating CXC chemokine ligand-12 (CXCL12) level can predict a 6-month outcome in Chinese patients with acute ischemic stroke (AIS). In a prospective study, C...

Xuan Cheng, Ya-Jun Lian, Yun-Qing Ma, Nan-Chang **e, Chuan-Jie Wu in Molecular Neurobiology (2017)

Article

Chronic Δ⁹-Tetrahydrocannabinol Administration Reduces IgE⁺B Cells but Unlikely Enhances Pathogenic SIV_mac251 Infection in Male Rhesus Macaques of Chinese Origin

Delta9-tetrahydrocannabinol (Δ⁹-THC) is the major psychoactive component of the cannabis plant. Δ⁹-THC has been used in the active ingredient of Marinol as an appetite stimulant for AIDS patients. Its impact on p...

Qiang Wei, Li Liu, Zhe Cong, **aoxian Wu, Hui Wang… in Journal of Neuroimmune Pharmacology (2016)

Article

Blocking c-Met–mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors

c-Met binds to and phosphorylates PARP1 in cancer cells, thereby reducing PARP1 binding to a PARP inhibitor; c-Met and PARP inhibitor combination therapy shows improved efficacy in preclinical models of breast...

Yi Du, Hirohito Yamaguchi, Yongkun Wei, Jennifer L Hsu, Hung-Ling Wang… in Nature Medicine (2016)

Article

Cannabinoid CB1 receptor signaling dichotomously modulates inhibitory and excitatory synaptic transmission in rat inner retina

In the inner retina, ganglion cells (RGCs) integrate and process excitatory signal from bipolar cells (BCs) and inhibitory signal from amacrine cells (ACs). Using multiple labeling immunohistochemistry, we fir...

**ao-Han Wang, Yi Wu, **ao-Fang Yang, Yanying Miao… in Brain Structure and Function (2016)

Article

Variants in the promoter region of CYP7A1 are associated with neuromyelitis optica but not with multiple sclerosis in the Han Chinese population

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are common autoimmune demyelinating disorders of the central nervous system. The exact etiology of each remains unclear. CYP7A1 was reported to be associated...

Gui-**an Zhao, Ying Liu, Zhen-**n Li, Chuan-Zhen Lv… in Neuroscience Bulletin (2013)

Article

Abnormal baseline brain activity in patients with HBV-related cirrhosis without overt hepatic encephalopathy revealed by resting-state functional MRI

Neurocognitive dysfunction of varying degrees is common in patients with hepatitis B virus-related cirrhosis (HBV-RC) without overt hepatic encephalopathy (OHE). However, the neurobiological mechanisms underly...

**ao-Fei Lv, Min Ye, Lu-Jun Han, Xue-Lin Zhang, Pei-Qiang Cai… in Metabolic Brain Disease (2013)

Article

Human Umbilical Cord-Derived Schwann-Like Cell Transplantation Combined with Neurotrophin-3 Administration in Dyskinesia of Rats with Spinal Cord Injury

Mesenchymal stem cells are capable of differentiating into Schwann-like cells. In this study, we induced human umbilical-cord mesenchymal stem cells (HUMSCs) in vitro into neurospheres constituted by neural st...

Guo Yan-Wu, Ke Yi-Quan, Li Ming, Cai Ying-Qian, Jiang **ao-Dan… in Neurochemical Research (2011)

Article

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

T cells must enter the brain to induce the autoimmune disease multiple sclerosis. Lydia Sorokin and her colleagues identify a mechanism by which T cells migrate across the endothelial basement membrane, a key ...

Chuan Wu, Fredrik Ivars, Per Anderson, Rupert Hallmann… in Nature Medicine (2009)