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    Article

    c-CBL is not required for leukemia induction by Bcr-Abl in mice

    Bcr-Abl tyrosine kinase activity is essential for the pathogenesis of chronic myeloid leukemia (CML). A number of Bcr-Abl substrates have been identified, but it is not clear which of these substrates are require...

    Daniela M Dinulescu, Lisa J Wood, Lei Shen, Marc Loriaux, Christopher L Corless… in Oncogene (2003)

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    Article

    Gastrointestinal stromal tumors (GISTs) with KIT and PDGFRA mutations have distinct gene expression profiles

    Most GISTs require oncogenic activation of the KIT or PDGFRA receptor tyrosine kinase proteins, and the genomic mechanisms of oncogene activation are heterogeneous. Notably, the kinase mutation type correlates wi...

    Subbaya Subramanian, Robert B West, Christopher L Corless, Wenbin Ou… in Oncogene (2004)