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  1. No Access

    Chapter

    Targeting mutant kinases in Gastrointestinal Stromal Tumors: A paradigm for molecular therapy of other sarcomas

    Michael C. Heinrich MD… in Targeting Treatment of Soft Tissue Sarcomas (2004)

  2. Article

    Open Access

    Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)

    About 10-15% of adult gastrointestinal stromal tumors (GIST) and the vast majority of pediatric GIST do not harbour KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutations (J Clin Oncol 22:3813–38...

    Margherita Nannini, Annalisa Astolfi, Milena Urbini, Valentina Indio… in BMC Cancer (2014)

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  3. Article

    Open Access

    Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs)

    Activating mutations of the receptor tyrosine kinase KIT are early events in the development of most gastrointestinal stromal tumors (GISTs). Although GISTs generally remain dependent on oncogenic KIT during tumo...

    Michael C. Heinrich, Janice Patterson, Carol Beadling… in Clinical Sarcoma Research (2019)

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