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    Article

    Integrative in situ map** of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease

    Complex diseases are characterized by spatiotemporal cellular and molecular changes that may be difficult to comprehensively capture. However, understanding the spatiotemporal dynamics underlying pathology can...

    Hu Zeng, Jiahao Huang, Haowen Zhou, William J. Meilandt in Nature Neuroscience (2023)

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    Article

    Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

    μ opioid receptors (MORs) expressed on primary afferent nociceptor neurons are responsible for two maladaptive side-effects of chronic opioid use: opioid tolerance and opioid-induced hyperalgesia (pain). A com...

    Gregory Corder, Vivianne L Tawfik, Dong Wang, Elizabeth I Sypek in Nature Medicine (2017)