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  1. Article

    Open Access

    Activation of Peripheral Blood CD4+ T-Cells in IBS is not Associated with Gastrointestinal or Psychological Symptoms

    Immune activation may underlie the pathogenesis of irritable bowel syndrome (IBS), but the evidence is conflicting. We examined whether peripheral CD4+ T-cells from IBS patients demonstrated immune activation ...

    Yasmin Nasser, Carlene Petes, Celine Simmers, Lilian Basso in Scientific Reports (2019)

  2. Article

    Open Access

    Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation

    Opioids remain the gold standard for the treatment of moderate to severe pain. However, their analgesic properties come with important side effects, including pruritus, which occurs frequently after systemic o...

    Helvira Melo, Lilian Basso, Mircea Iftinca, Wallace K. MacNaughton in Scientific Reports (2018)

  3. Article

    Open Access

    Prolonged AT1R activation induces CaV1.2 channel internalization in rat cardiomyocytes

    The cardiac L-type calcium channel is a multi-subunit complex that requires co-assembling of the pore-forming subunit CaV1.2 with auxiliary subunits CaVα2δ and CaVβ. Its traffic has been shown to be controlled by...

    Tamara Hermosilla, Matías Encina, Danna Morales, Cristian Moreno in Scientific Reports (2017)