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    Article

    Targeted therapies for cardiac diseases

    Heart failure is a systemic disease in which neuroendocrine activation, inflammation and metabolic changes can impair cardiac function. In addition, variants in genes encoding sarcomeric proteins can predispos...

    Christoph Maack, Jil C. Tardiff in Nature Reviews Cardiology (2022)

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    A pathophysiological compass to personalize antianginal drug treatment

    Myocardial ischaemia results from coronary macrovascular or microvascular dysfunction compromising the supply of oxygen and nutrients to the myocardium. The underlying pathophysiological processes are manifold...

    Edoardo Bertero, Gerd Heusch, Thomas Münzel, Christoph Maack in Nature Reviews Cardiology (2021)

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    Reply to ‘Metabolic remodelling in heart failure revisited’

    Edoardo Bertero, Christoph Maack in Nature Reviews Cardiology (2018)

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    Article

    Metabolic remodelling in heart failure

    The heart consumes large amounts of energy in the form of ATP that is continuously replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by glycolysis. To adapt the ATP supply effic...

    Edoardo Bertero, Christoph Maack in Nature Reviews Cardiology (2018)