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    Article

    The prognostic value of pain in castration-sensitive prostate cancer

    Cancer-related pain, usually associated with bone metastases, is a frequent and debilitating morbidity in patients with prostate cancer. To date there are only limited data regarding the prognostic role of pai...

    Roberto Iacovelli, Chiara Ciccarese, Orazio Caffo in Prostate Cancer and Prostatic Diseases (2020)

  2. Article

    Correction to: Cabozantinib After a Previous Immune Checkpoint Inhibitor in Metastatic Renal Cell Carcinoma: A Retrospective Multi-Institutional Analysis

    While typesetting the article the Table 3 column/row entries are interchanged. Please find below the updated Table

    Roberto Iacovelli, Chiara Ciccarese, Gaetano Facchini, Michele Milella in Targeted Oncology (2020)

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    Article

    Cabozantinib After a Previous Immune Checkpoint Inhibitor in Metastatic Renal Cell Carcinoma: A Retrospective Multi-Institutional Analysis

    Angiogenesis has been recognized as the most important factor for tumor invasion, proliferation, and progression in metastatic renal cell carcinoma (mRCC). However, few clinical data are available regarding th...

    Roberto Iacovelli, Chiara Ciccarese, Gaetano Facchini, Michele Milella in Targeted Oncology (2020)

  4. Article

    Open Access

    Second line therapy with axitinib after only prior sunitinib in metastatic renal cell cancer: Italian multicenter real world SAX study final results

    This multi-institutional retrospective real life study was conducted in 22 Italian Oncology Centers and evaluated the role of Axitinib in second line treatment in not selected mRCC patients.

    Gaetano Facchini, Sabrina Rossetti in Journal of Translational Medicine (2019)

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    Article

    Comparison Between Prognostic Classifications in De Novo Metastatic Hormone Sensitive Prostate Cancer

    The CHAARTED and LATITUDE trials demonstrated improved outcomes with docetaxel or abiraterone plus androgen deprivation therapy in metastatic hormone sensitive prostate cancer (mHSPC) using two different progn...

    Roberto Iacovelli, Chiara Ciccarese, Claudia Mosillo, Davide Bimbatti in Targeted Oncology (2018)

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    Article

    The Tumor Entity Denominated “clear cell-papillary renal cell carcinoma” According to the WHO 2016 new Classification, have the Clinical Characters of a Renal Cell Adenoma as does Harbor a Benign Outcome

    The new WHO 2016 classification of renal neoplasia encounters the new entity called “clear cell papillary renal cell carcinoma” (ccpRCC). The ccpRCC has been long included as a subtype of clear cell RCC histot...

    Francesco Massari, Chiara Ciccarese, Ondrej Hes in Pathology & Oncology Research (2018)

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    Article

    Investigating BRCA Mutations: A Breakthrough in Precision Medicine of Castration-Resistant Prostate Cancer

    Despite the development of novel effective therapeutic strategies, metastatic castration-resistant prostate cancer (mCRPC) remains a disease with a lethal course and a high biological and molecular heterogenei...

    Alessandra Modena, Roberto Iacovelli, Aldo Scarpa, Matteo Brunelli in Targeted Oncology (2016)

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    Article

    Targeting Met and VEGFR Axis in Metastatic Castration-Resistant Prostate Cancer: ‘Game Over’?

    Despite recent advances that have been made in the therapeutic landscape of metastatic castration-resistant prostate cancer (mCRPC), effective management of bone metastases remains a key goal not yet reached. ...

    Alessandra Modena, Francesco Massari, Chiara Ciccarese in Targeted Oncology (2016)

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    Article

    Magnitude of PD-1, PD-L1 and T Lymphocyte Expression on Tissue from Castration-Resistant Prostate Adenocarcinoma: An Exploratory Analysis

    Recent therapeutic strategies for castration-resistant prostate cancer have focused on immunomodulation, especially the PD-1/PD-L1 pathway related to tumor-infiltrating lymphocytes. Few cases of castration-res...

    Francesco Massari, Chiara Ciccarese, Anna Caliò, Enrico Munari in Targeted Oncology (2016)

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    Article

    The route to personalized medicine in bladder cancer: where do we stand?

    Recent advances in molecular biology and drug design have described novel targets in bladder cancer. EGFR, fibroblast growth factor receptor (FGFR), VEGFR, phosphoinositide 3-kinase (PI3K)/AKT/mammalian target...

    Francesco Massari, Chiara Ciccarese, Matteo Santoni, Matteo Brunelli in Targeted Oncology (2015)