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  1. No Access

    Article

    Nucleophosmin/B23 promotes endometrial cancer cell escape from macrophage phagocytosis by increasing CD24 expression

    Despite recent therapeutic breakthroughs, advanced and/or recurrent endometrial cancer still poses a significant health burden globally. While immunotherapy can theoretically lead to durable responses, the ben...

    Chiao-Yun Lin, Chia-Lung Tsai, Angel Chao, Li-Yu Lee… in Journal of Molecular Medicine (2021)

  2. No Access

    Article

    Synergistic effects of pazopanib and hyperthermia against uterine leiomyosarcoma growth mediated by downregulation of histone acetyltransferase 1

    Pazopanib—a multitargeted tyrosine kinase inhibitor with prominent antiangiogenic effects—has shown promise in the treatment of soft-tissue sarcomas. Hyperthermia has been also applied as an adjunctive treatme...

    Chiao-Yun Lin, Angel Chao, Ren-Chin Wu, Li-Yu Lee… in Journal of Molecular Medicine (2020)

  3. No Access

    Article

    SOX4 activates CXCL12 in hepatocellular carcinoma cells to modulate endothelial cell migration and angiogenesis in vivo

    The overexpression of SOX4 in various kinds of cancer cells was associated with poor prognosis for patients. The role of SOX4 in angiogenesis and tumor microenvironment modulation was recently documented in br...

    Chi-Neu Tsai, Shu-Chuan Yu, Chao-Wei Lee, Jong-Hwei Su Pang, Chun-Hsin Wu… in Oncogene (2020)

  4. No Access

    Article

    The combination of everolimus and terameprocol exerts synergistic antiproliferative effects in endometrial cancer: molecular role of insulin-like growth factor binding protein 2

    Oncogenic PIK3CA mutations are common in endometrial cancers, and the PI3K/AKT/mTOR pathway is targetable by drugs. We sought to investigate whether the combination of an mTOR inhibitor, everolimus (RAD001), and ...

    Angel Chao, Chiao-Yun Lin, Ren-Chin Wu, Yun-Shien Lee… in Journal of Molecular Medicine (2018)

  5. Article

    Open Access

    Stress-induced phosphoprotein 1 acts as a scaffold protein for glycogen synthase kinase-3 beta-mediated phosphorylation of lysine-specific demethylase 1

    Stress-induced phosphoprotein 1 (STIP1)—a co-chaperone of heat shock proteins—promotes cell proliferation and may act as an oncogenic factor. Similarly, glycogen synthase kinase-3 beta (GSK3β)-mediated phospho...

    Chia-Lung Tsai, An-Shine Chao, Shih-Ming Jung, Chiao-Yun Lin, Angel Chao… in Oncogenesis (2018)

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  6. No Access

    Article

    Estrogen stimulates the proliferation of human endometrial cancer cells by stabilizing nucleophosmin/B23 (NPM/B23)

    Unopposed estrogen exposure is an important factor in the tumorigenesis of endometrial cancer. Nucleophosmin/B23 (NPM/B23), a phosphoprotein that has pleiotropic functions in cells, plays an important role in ...

    Angel Chao, Chiao-Yun Lin, Chia-Lung Tsai, Swei Hsueh… in Journal of Molecular Medicine (2013)