5 Result(s)
within
Cheol-Hee Choi
Cell Biology
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Article
Histone H4 deacetylation down-regulates catalase gene expression in doxorubicin-resistant AML subline
We explored if epigenetic mechanisms could be involved in the down-regulated expression of catalase gene (CAT) in the doxorubicin-resistant acute myelogenous leukemia (AML)-2/DX100 cells. Down-regulated CAT expre...
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Article
Open AccessABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal
One of the major problems related with anticancer chemotherapy is resistance against anticancer drugs. The ATP-binding cassette (ABC) transporters are a family of transporter proteins that are responsible for ...
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Article
Open AccessFunctional and structural characteristics of anticancer peptide Pep27 analogues
A secreted peptide Pep27 initiates the cell death program in S. pneumoniae through signal transduction. This study was undertaken to evaluate the relation between the structure and cytotoxic activity of Pep27 and...
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Article
Open AccessMolecular mechanisms of heptaplatin effective against cisplatin-resistant cancer cell lines: less involvement of metallothionein
Heptaplatin is a new platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant cancer cell lines (Cancer Chemother Pharmacol 1995; 35: 441).
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Article
Reactive Oxygen Species-specific Mechanisms of Drug Resistance in Paraquat-resistant Acute Myelogenous Leukemia Sublines
Reactive oxygen species (ROS)-specific mechanisms of drug resistance were explored in paraquat (PQ)-resistant acute myelogenous leukemia cell (OCI/AML-2) sublines. For this, PQ-resistant AML sublines, AML-2/PQ...
