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Article
Inhibitory Effects of Gynostemma Pentaphyllum on the UV Induction of Bacteriophage λ in Lysogenic Escherichia coli
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Article
A novel finding for enterovirus virulence from the capsid protein VP1 of EV71 circulating in mainland China
Enterovirus 71 (EV71) is a neurotropic virus that causes various clinical manifestations in young children, ranging from asymptomatic to fatal. Different pathotypes of EV71 notably differ in virulence. Several...
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Article
Open AccessHepatitis B virus promotes cancer cell migration by downregulating miR-340-5p expression to induce STAT3 overexpression
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide, and infection with hepatitis B virus (HBV) is a leading cause of HCC. Previous studies have demonstrated that expre...
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Article
Open AccessInhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1
Arachidonic acid (AA) metabolic enzymes including cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11 play important roles in glioma angiogenesis. Thus, the...
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Article
Open AccessSensing of autoinducer-2 by functionally distinct receptors in prokaryotes
Autoinducer-2 (AI-2) is a quorum sensing signal that mediates communication within and between many bacterial species. However, its known receptors (LuxP and LsrB families) are not found in all the bacteria ca...
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Article
A time-series InSAR processing chain for wide-area geohazard identification
Time-series InSAR technology has been widely applied to the identification of various types of surface deformation information, but its traditional processing chain of being applied to the detection, extractio...
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Article
Open AccessNatural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding
Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune evasion. However, the K-D-K-E catalytic motif o...
