Skip to main content

2 Result(s)

within Chengpeng Fan Remove this filter Oncology Remove this filter

and

  1. Article

    Open Access

    Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding

    Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune evasion. However, the K-D-K-E catalytic motif o...

    Jikai Deng, Shimin Yang, Yingjian Li, Xue Tan… in Signal Transduction and Targeted Therapy (2024)

    Download PDF (7144 KB) View Article

  2. Article

    Open Access

    Inhibition of COX-2, mPGES-1 and CYP4A by isoliquiritigenin blocks the angiogenic Akt signaling in glioma through ceRNA effect of miR-194-5p and lncRNA NEAT1

    Arachidonic acid (AA) metabolic enzymes including cyclooxygenase-2 (COX-2), microsomal prostaglandin E synthase-1 (mPGES-1) and cytochrome P450 (CYP) 4A11 play important roles in glioma angiogenesis. Thus, the...

    Chenlong Wang, Yaxin Chen, Yang Wang… in Journal of Experimental & Clinical Cancer … (2019)

    Download PDF (6113 KB) View Article