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Article

Natural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding

Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune evasion. However, the K-D-K-E catalytic motif o...

Jikai Deng, Shimin Yang, Yingjian Li, Xue Tan… in Signal Transduction and Targeted Therapy (2024)