-
Article
Open AccessA comprehensive genetic map of cytokine responses in Lyme borreliosis
The incidence of Lyme borreliosis has risen, accompanied by persistent symptoms. The innate immune system and related cytokines are crucial in the host response and symptom development. We characterized cytoki...
-
Article
Open AccessGenome-wide analyses in Lyme borreliosis: identification of a genetic variant associated with disease susceptibility and its immunological implications
Genetic variation underly inter-individual variation in host immune responses to infectious diseases, and may affect susceptibility or the course of signs and symptoms.
-
Article
Open AccessEuropean and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date...
-
Article
Open AccessNasal DNA methylation at three CpG sites predicts childhood allergic disease
Childhood allergic diseases, including asthma, rhinitis and eczema, are prevalent conditions that share strong genetic and environmental components. Diagnosis relies on clinical history and measurements of all...
-
Article
Open AccessReprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma
Myeloid cells, crucial players in antitumoral defense, are affected by tumor-derived factors and treatment. The role of myeloid cells and their progenitors prior to tumor infiltration is poorly understood. Her...
-
Article
Open AccessIRF7 and RNH1 are modifying factors of HIV-1 reservoirs: a genome-wide association analysis
Combination antiretroviral treatment (cART) cannot eradicate HIV-1 from the body due to the establishment of persisting viral reservoirs which are not affected by therapy and reinitiate new rounds of HIV-1 rep...
-
Article
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantita...
-
Article
Open AccessIntegration of metabolomics, genomics, and immune phenotypes reveals the causal roles of metabolites in disease
Recent studies highlight the role of metabolites in immune diseases, but it remains unknown how much of this effect is driven by genetic and non-genetic host factors.
-
Article
Open AccessEpigenome-wide association study identifies DNA methylation markers for asthma remission in whole blood and nasal epithelium
Asthma is a chronic respiratory disease which is not curable, yet some patients experience spontaneous remission. We hypothesized that epigenetic mechanisms may be involved in asthma remission.
-
Article
Open AccessMulti-omics examination of Q fever fatigue syndrome identifies similarities with chronic fatigue syndrome
Q fever fatigue syndrome (QFS) is characterised by a state of prolonged fatigue that is seen in 20% of acute Q fever infections and has major health-related consequences. The molecular mechanisms underlying QF...
-
Article
Open AccessDNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies
DNA methylation has been shown to be associated with adiposity in adulthood. However, whether similar DNA methylation patterns are associated with childhood and adolescent body mass index (BMI) is largely unkn...
-
Article
Open AccessEpigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated...
-
Article
Open AccessSoluble immune markers in the different phases of chronic hepatitis B virus infection
Chronic hepatitis B virus (HBV) infection may follow four different consecutive phases, which are defined by virology as well as biochemical markers and differ in terms of prognosis and need for antiviral trea...
-
Article
Open AccessMeta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birt...
-
Article
Open AccessGenome-wide DNA methylation and long-term ambient air pollution exposure in Korean adults
Ambient air pollution is associated with numerous adverse health outcomes, but the underlying mechanisms are not well understood; epigenetic effects including altered DNA methylation could play a role. To eval...
-
Article
Open AccessThe emerging landscape of dynamic DNA methylation in early childhood
DNA methylation has been found to associate with disease, aging and environmental exposure, but it is unknown how genome, environment and disease influence DNA methylation dynamics in childhood.
-
Article
Open AccessTo aggregate or not to aggregate high-dimensional classifiers
High-throughput functional genomics technologies generate large amount of data with hundreds or thousands of measurements per sample. The number of sample is usually much smaller in the order of ten or hundred...
-
Article
Comparing chemical fingerprints of herbal medicines using modified window target-testing factor analysis
A “chromatographic fingerprint” of a herbal medicine is essentially its chromatographic spectrum: a characteristic representation of its chemical components, some of which are pharmacologically active. Since a...
-
Article
Resolution and identification of the acidic fraction of a petroleum ether extract ofRadix Rehmanniae Preparata by an evolving chemometric approach
An evolving approach is described for analyzing the acidic components of a petroleum ether extract of Radix Rehmanniae Preparata. The latter was extracted, separated and derivatized. The subsequent separation ...
-
Article
Resolution of the essential constituents of Ramulus cinnamomi by an evolving chemometric approach
The analysis of complex mixtures, such as those of traditional Chinese medicine (TCM), is difficult by conventional methods of analysis. Chemometric methods provide a new way to solve such problems. Subwindow...
