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Article
Enhanced homing of mesenchymal stem cells for in situ niche remodeling and bone regeneration
Mesenchymal stem cells (MSCs) transplantation is a promising strategy for osteoporosis treatment. However, limited sources and poor tissue-homing efficiency limit their clinical capabilities. In this study, we...
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Article
Open AccessMenstrual blood-derived mesenchymal stem cells combined with collagen I gel as a regenerative therapeutic strategy for degenerated disc after discectomy in rats
Annulus fibrosis (AF) defects have been identified as the primary cause of disc herniation relapse and subsequent disc degeneration following discectomy. Stem cell-based tissue engineering offers a promising a...
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Chapter
Pareto Deterministic Policy Gradients and Its Application in 6G Networks
In this chapter, we introduce a reinforcement learning (RL)-based approach to jointly optimize cell load balance and network throughput as a potential AI/ML-based use case for sixth-generation cellular systems...
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Article
Multiple Dimensions of using Mesenchymal Stem Cells for Treating Liver Diseases: From Bench to Beside
Liver diseases impose a huge burden worldwide. Although hepatocyte transplantation has long been considered as a potential strategy for treating liver diseases, its clinical implementation has created some obv...
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Article
Open AccessHuman menstrual blood-derived stem cells reverse sorafenib resistance in hepatocellular carcinoma cells through the hyperactivation of mitophagy
Sorafenib is a first-line drug targeting the RTK-MAPK signalling pathway used to treat advanced hepatocellular carcinoma (HCC). However, tumour cells readily develop sorafenib resistance, limiting long-term th...
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Chapter
Process Analytical Technology (PAT) for Lyophilization Process Monitoring and End Point Detection
Process analytical technology (PAT) is critical during freeze drying at extreme conditions (low temperature and low pressure), and latest PAT tools are reviewed in this chapter. These PAT tools are first discu...
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Chapter
Challenges and Considerations in the Development of a High Protein Concentration Lyophilized Drug Product
The lyophilized high concentration protein drug products have the advantages of product stability suitable for ADC and other stability sensitive molecules, speed to first-in-human clinical trials (shorter deve...
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Article
Open AccessImmune checkpoint inhibitors and the risk of major atherosclerotic cardiovascular events in patients with high-risk or advanced melanoma: a retrospective cohort study
Immune checkpoint inhibitors (ICI) are associated with immune-mediated adverse effects, potentially involving any organ. ICI has also been associated with an increased risk of cardiovascular disease in cancer ...
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Article
Open AccessTargeting Myc-driven stress vulnerability in mutant KRAS colorectal cancer
Mutant KRAS is a key driver in colorectal cancer (CRC) and promotes Myc translation and Myc-dependent stress adaptation and proliferation. Here, we report that the combination of two FDA-approved drugs Bortezomib...
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Article
Mesenchymal stem cell-based treatments for COVID-19: status and future perspectives for clinical applications
As a result of cross-species transmission in December 2019, the coronavirus disease 2019 (COVID-19) became a serious endangerment to human health and the causal agent of a global pandemic. Although the number ...
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Protocol
Rapid In Vivo Quantification of Creatine Kinase Activity by Phosphorous-31 Magnetic Resonance Spectroscopic Fingerprinting (31P-MRSF)
Creatine kinase (CK) plays an important role in tissue metabolism by providing a buffering mechanism for maintaining a constant supply of adenosine triphosphate (ATP) during metabolic perturbations. Phosphorou...
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Chapter
CSR Practices in the Vietnamese Food Companies: Evidence from an Emerging Economy
Social and environmental sustainability concerns have been critical in Asian emerging economies due to their rapid economic development. Yet there is limited research into the motivations for businesses to pur...
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Article
Open AccessSmall extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine
Menstrual blood-derived mesenchymal stem cells (MenSCs) have great potential in regenerative medicine. MenSC has received increasing attention owing to its impressive therapeutic effects in both preclinical an...
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Article
Open AccessHuman menstrual blood-derived stem cells mitigate bleomycin-induced pulmonary fibrosis through anti-apoptosis and anti-inflammatory effects
Idiopathic pulmonary fibrosis is a kind of diffuse interstitial lung disease, the pathogenesis of which is unclear, and there is currently a lack of good treatment to improve the survival rate. Human menstrual...
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Article
Clinical study using mesenchymal stem cells for the treatment of patients with severe COVID-19
The Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was identified in December 2019. The symptoms include fever, cough, dyspnea, early symptom of sputum, and acute respiratory distress syndrome (ARDS)...
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Article
Open AccessRationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients
In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, capital city of Hubei province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per day. Less than 100 days later, the W...
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Chapter
Chapter 14: Practical Considerations in High Concentration Formulation Development for Monoclonal Antibody Drug Products
This book chapter covers practical consideration and strategies in develo** high concentration formulations and drug products for commercial use. The discussions presented in this chapter are based on author...
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Article
Open AccessMenstrual blood-derived stem cells: toward therapeutic mechanisms, novel strategies, and future perspectives in the treatment of diseases
Menstrual blood-derived stem cells (MenSCs) have great potential in the treatment of various diseases. As a novel type of mesenchymal stem cells (MSCs), MenSCs have attracted more interest due to their therape...
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Article
Open AccessAdopting the direct anterior approach: experience and learning curve in a Chinese patient population
There are concerns regarding the complications encountered during the learning curve when switching to a direct anterior approach (DAA) for total hip arthroplasty (THA). The purpose of our study is to report o...
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Article
Open AccessGenome-wide DNA methylation and hydroxymethylation analysis reveal human menstrual blood-derived stem cells inhibit hepatocellular carcinoma growth through oncogenic pathway suppression via regulating 5-hmC in enhancer elements
Epigenetic alteration is an important indicator of crosstalk between cancer cells and surrounding microenvironment components including mesenchymal stem cells (MSC). Human menstrual blood-derived stem cells (M...
