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  1. Article

    Open Access

    Effect of Infusion Set Replacement Intervals on Central Line-Associated Bloodstream Infection in the Intensive Care Unit: Study Protocol of the INSPIRATION Study

    The replacement intervals for infusion sets may differ among healthcare institutions, which may have an impact on the occurrence of central line-associated bloodstream infections (CLABSI). Nevertheless, there ...

    Dandan Xu, Chang Hu, Jie **ong, Haiyan Huang in Infectious Diseases and Therapy (2024)

  2. Article

    Open Access

    Application of Machine Learning for Clinical Subphenotype Identification in Sepsis

    Sepsis is a heterogeneous clinical syndrome. Identification of sepsis subphenotypes could lead to allowing more precise therapy. However, there is a lack of models to identify the subphenotypes in such patient...

    Chang Hu, Yiming Li, Fengyun Wang, Zhiyong Peng in Infectious Diseases and Therapy (2022)

  3. Article

    Open Access

    Explainable Machine-Learning Model for Prediction of In-Hospital Mortality in Septic Patients Requiring Intensive Care Unit Readmission

    Septic patients requiring intensive care unit (ICU) readmission are at high risk of mortality, but research focusing on the association of ICU readmission due to sepsis and mortality is limited. The aim of thi...

    Chang Hu, Lu Li, Yiming Li, Fengyun Wang, Bo Hu in Infectious Diseases and Therapy (2022)

  4. Article

    Open Access

    Interpretable Machine Learning for Early Prediction of Prognosis in Sepsis: A Discovery and Validation Study

    This study aimed to develop and validate an interpretable machine-learning model based on clinical features for early predicting in-hospital mortality in critically ill patients with sepsis.

    Chang Hu, Lu Li, Weipeng Huang, Tong Wu, Qiancheng Xu in Infectious Diseases and Therapy (2022)

  5. Article

    Open Access

    Association of Thiamine Use with Outcomes in Patients with Sepsis and Alcohol Use Disorder: An Analysis of the MIMIC-III Database

    The association between thiamine use and clinical outcomes among patients with sepsis and alcohol use disorder (AUD) is unclear.

    Chang Hu, Tong Wu, Siqing Ma, Weipeng Huang in Infectious Diseases and Therapy (2022)