9 Result(s)
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Article
Open AccessThe SGLT2 inhibitor Empagliflozin promotes post-stroke functional recovery in diabetic mice
Type-2 diabetes (T2D) worsens stroke recovery, amplifying post-stroke disabilities. Currently, there are no therapies targeting this important clinical problem. Sodium-glucose cotransporter 2 inhibitors (SGLT2...
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Open AccessDiet-induced weight loss in obese/diabetic mice normalizes glucose metabolism and promotes functional recovery after stroke
Post-stroke functional recovery is severely impaired by type 2 diabetes (T2D). This is an important clinical problem since T2D is one of the most common diseases. Because weight loss-based strategies have been...
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Article
Open AccessEstimated glucose disposal rate and risk of stroke and mortality in type 2 diabetes: a nationwide cohort study
Insulin resistance contributes to the development of type 2 diabetes (T2D) and is also a cardiovascular risk factor. The aim of this study was to investigate the potential association between insulin resistanc...
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Article
Open AccessGLP-1 secretion in acute ischemic stroke: association with functional outcome and comparison with healthy individuals
Glucagon-like peptide-1 (GLP-1) treatment has been shown to reduce stroke incidence in diabetes and also to be neuroprotective in experimental stroke models. The prognostic value of endogenous levels of GLP-1 ...
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Article
Open AccessThe effect of DPP-4 inhibition to improve functional outcome after stroke is mediated by the SDF-1α/CXCR4 pathway
Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are approved drugs for the treatment of hyperglycemia in patients with type 2 diabetes. These effects are mainly mediated by inhibiting endogenous glucagon-...
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Article
Open AccessThe high need for trials assessing functional outcome after stroke rather than stroke prevention with GLP-1 agonists and DPP-4 inhibitors
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Article
GLP-1R activation for the treatment of stroke: Updating and future perspectives
Stroke is the leading cause of adult disability in Westernized societies with increased incidence along ageing and it represents a major health and economical threat. Inactive lifestyle, smoking, hypertension,...
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Article
Metformin protects against lipoapoptosis and enhances GLP-1 secretion from GLP-1-producing cells
Metformin is the most frequently prescribed drug for treatment of type 2 diabetes. It improves insulin resistance and glycemia by reducing hepatic gluconeogenesis. In addition, diabetic patients on metformin t...
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Chapter
A Model System for the Study of Estrogen Receptor Activity in Cells of Neural Origin
For quite a long-time we have known that estrogens can modulate brain activities and estrogen receptors (ER) are present in a number of brain regions [1]. However, the study of the activity of estrogens in the...
