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  1. No Access

    Article

    Genomics and drug profiling of fatal TCF3-HLF−positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options

    Jean-Pierre Bourquin, Martin Stanulla and colleagues report whole genome, whole exome and transcriptome sequencing of TCF3-HLF fusion–positive acute lymphoblastic leukemia. Drug response profiling in patient-deri...

    Ute Fischer, Michael Forster, Anna Rinaldi, Thomas Risch… in Nature Genetics (2015)

  2. No Access

    Article

    Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

    Stefan Pfister and the ICGC PedBrain Tumor Project report whole-genome sequencing of 96 pilocytic astrocytomas. They identify recurrent activating mutations in FGFR1 and PTPN11 and novel NTRK2 fusion genes.

    David T W Jones, Barbara Hutter, Natalie Jäger, Andrey Korshunov… in Nature Genetics (2013)

  3. No Access

    Article

    Meet Me Halfway: When Genomics Meets Structural Bioinformatics

    The DNA sequencing technology developed by Frederick Sanger in the 1970s established genomics as the basis of comparative genetics. The recent invention of next-generation sequencing (NGS) platform has added a...

    Sungsam Gong, Catherine L. Worth… in Journal of Cardiovascular Translational Re… (2011)