29 Result(s)

Article

Multicenter development of a PET-based risk assessment tool for product-specific outcome prediction in large B-cell lymphoma patients undergoing CAR T-cell therapy

The emergence of chimeric antigen receptor (CAR) T-cell therapy fundamentally changed the management of individuals with relapsed and refractory large B-cell lymphoma (LBCL). However, real-world data have show...

Conrad-Amadeus Voltin, Andrea Paccagnella… in European Journal of Nuclear Medicine and M… (2024)

Article

Patterns of PET-positive residual tissue at interim restaging and risk of treatment failure in advanced-stage Hodgkin’s lymphoma: an analysis of the randomized phase III HD18 trial by the German Hodgkin Study Group

Response-adapted treatment using early interim functional imaging with PET after two cycles of chemotherapy (PET-2) for advanced-stage Hodgkin’s lymphoma (AS-HL) is the standard of care in several countries. H...

Justin Ferdinandus, Lutz van Heek… in European Journal of Nuclear Medicine and M… (2024)

Article

Follow-up of the GHSG HD16 trial of PET-guided treatment in early-stage favorable Hodgkin lymphoma

The primary analysis of the GHSG HD16 trial indicated a significant loss of tumor control with PET-guided omission of radiotherapy (RT) in patients with early-stage favorable Hodgkin lymphoma (HL). This analys...

Michael Fuchs, Anne Sophie Jacob, Helen Kaul, Carsten Kobe, Georg Kuhnert… in Leukemia (2024)

Article

Dual-tracer PET/CT protocol with [¹⁸F]FDG and [⁶⁸Ga]Ga-FAPI-46 outperforms single-tracer PET/CT with [¹⁸F]FDG in different cancer types, resulting in larger functional and gross tumor volume

Fibroblast activation protein (FAP) detected by positron-emission tomography (PET) using fibroblast activation protein inhibitor (FAPI) appears to be a promising target for cancer imaging, staging, and therapy...

Simone Wegen, Jasmin Weindler, Conrad-Amadeus Voltin… in Strahlentherapie und Onkologie (2024)

Article

How to attract young talent to nuclear medicine step 1: a survey conducted by the EANM Oncology and Theranostics Committee to understand the expectations of the next generation

Valentina Ambrosini, Sofia Carrilho Vaz… in European Journal of Nuclear Medicine and M… (2023)

Article

Threshold for defining PSMA-positivity prior to ¹⁷⁷Lu-PSMA therapy: a comparison of [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]F-DCFPyL in metastatic prostate cancer

In 2022, the American Food and Drug Administration and the European Medicines Agency approved [¹⁷⁷Lu]Lu-PSMA-617 (PLUVICTO™, Novartis AG, Basel, Switzerland) for radionuclide therapy with prostate-specific membra...

Jan Heilinger, Jasmin Weindler, Katrin Sabine Roth, Philipp Krapf… in EJNMMI Research (2023)

Article

Defining the role of nuclear medicine in haematological tumours—EANM Focus 4: consensus on molecular imaging and therapy in haematological tumours

Cristina Nanni, Carsten Kobe, Ken Herrmann… in European Journal of Nuclear Medicine and M… (2023)

Article

Head-to-Head Comparison of [⁶⁸ Ga]Ga-FAPI-46-PET/CT and [¹⁸F]F-FDG-PET/CT for Radiotherapy Planning in Head and Neck Cancer

In head and neck cancers (HNCs), fibroblast activation protein (FAP) is expressed by cancer-associated fibroblasts (CAFs) in the tumor microenvironment. Preliminary evidence suggests that detection and staging...

Simone Wegen, Lutz van Heek, Philipp Linde, Karina Claus… in Molecular Imaging and Biology (2022)

Article

Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer

Activation of MAPK signaling via BRAF mutations may limit the activity of EGFR inhibitors in EGFR-mutant lung cancer patients. However, the impact of BRAF mutations on the selection and fitness of emerging resist...

Diana Schaufler, David F. Ast, Hannah L. Tumbrink, Nima Abedpour… in npj Precision Oncology (2021)

Article

Reply to Paulo Schiavom Duarte

Julian M. M. Rogasch, Carsten Kobe in European Journal of Nuclear Medicine and M… (2021)

Article

Moving the goalposts while scoring―the dilemma posed by new PET technologies

Julian M.M. Rogasch, Ronald Boellaard… in European Journal of Nuclear Medicine and M… (2021)

Article

[¹⁸F]-JK-PSMA-7 PET/CT Under Androgen Deprivation Therapy in Advanced Prostate Cancer

PSMA imaging is frequently used for monitoring of androgen deprivation therapy (ADT) in prostate cancer. In a previous study, [¹⁸F]-JK-PSMA-7 exhibited favorable properties for tumor localization after biochemica...

Felix Dietlein, Peter Mueller, Carsten Kobe… in Molecular Imaging and Biology (2021)

Article

Pentixafor PET/CT for imaging of chemokine receptor 4 expression in esophageal cancer – a first clinical approach

Expression of CXCR4, a chemokine (C-X-C motif) receptor that plays a central role in tumor growth and metastasis of circulating tumor cells, has been described in a variety of solid tumors. A high expression o...

Philipp Linde, Christian Baues, Simone Wegen, Maike Trommer… in Cancer Imaging (2021)

Article

EANM position paper on article 56 of the Council Directive 2013/59/Euratom (basic safety standards) for nuclear medicine therapy

The EC Directive 2013/59/Euratom states in article 56 that exposures of target volumes in nuclear medicine treatments shall be individually planned and their delivery appropriately verified. The Directive also...

Mark Konijnenberg, Ken Herrmann… in European Journal of Nuclear Medicine and M… (2021)

Article

Biodistribution and radiation dosimetry of [¹⁸F]-JK-PSMA-7 as a novel prostate-specific membrane antigen-specific ligand for PET/CT imaging of prostate cancer

We investigated the whole-body distribution and the radiation dosimetry of [¹⁸F]-JK-PSMA-7, a novel ¹⁸F-labeled PSMA-ligand for PET/CT imaging of prostate cancer.

Melanie Hohberg, Carsten Kobe, Philipp Krapf, Philipp Täger… in EJNMMI Research (2019)

Article

Impact of different approaches to calculation of treatment activities on achieved doses in radioiodine therapy of benign thyroid diseases

Radioiodine has been used for the treatment of benign thyroid diseases for over 70 years. However, internationally, there is no common standard for pretherapeutic dosimetry to optimally define the individual t...

Jochen Hammes, Lutz van Heek, Melanie Hohberg, Manuel Reifegerst… in EJNMMI Physics (2018)

Article

Dosimetry-based treatment planning for molecular radiotherapy: a summary of the 2017 report from the Internal Dosimetry Task Force

The European directive on basic safety standards (Council directive 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. The directive comes into operation February 2...

Caroline Stokke, Pablo Minguez Gabiña, Pavel Solný, Francesco Cicone… in EJNMMI Physics (2017)

Article

ALK ^G1269A mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor

Inflammatory myofibroblastic tumors are rare mesenchymal neoplasms frequently harboring oncogenic chromosomal rearrangements, most commonly, involving the ALK (anaplastic lymphoma kinase) gene. Treatment of this ...

Sebastian Y. F. Michels, Andreas H. Scheel, Thomas Wündisch… in npj Precision Oncology (2017)