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Article
Open AccessCutaneous melanoma in older patients
In industrialized countries, the aging population is steadily rising. The incidence of cutaneous malignant melanoma (CMM) is highest in old people. This study focuses on the clinicopathological profile of CMM ...
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Article
Open AccessMalignant Melanoma: Direct Costs by Clinical and Pathological Profile
A number of studies have examined the impact of tumor stage on direct health care costs of patients with melanoma. This study aimed to investigate the association between the direct costs for melanoma and the ...
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Article
Quality management of cutaneous melanoma: impact on short-term outcomes and costs
Promoting standardization and quality assurance (QA) may guarantee better outcomes for patients and ensure a better allocation of healthcare system resources.
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Article
Oncological outcome of videoscopic groin dissection for lymph node metastasis from melanoma
Videoscopic inguinal lymphadenectomy (VIL) represents an innovative approach for patients with melanoma lymph node (LN) metastases, mainly aimed at lowering wound-related morbidity. However, long-term data on ...
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Article
Open AccessGender-specific associations between polymorphisms of the circadian gene RORA and cutaneous melanoma susceptibility
Melanoma is the deadliest of skin cancers and has an increasing annual incidence worldwide. It is a multi-factorial disease most likely arising from both genetic predisposition and environmental exposure to ul...
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Article
Open AccessThe surgical treatment of non-metastatic melanoma in a Clinical National Melanoma Registry Study Group (CNMR): a retrospective cohort quality improvement study to reduce the morbidity rates
Reproducible, high-quality surgery is a key point in the management of cancer patients. Quality indicators for surgical treatment of melanoma has been presented with benchmarks but data on morbidity are still ...
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Chapter
Surgical Technique and Indications for Radical Dissection: Axilla
The main purpose of lymphadenectomy in patients affected by lymph node metastases from melanoma is to provide locoregional control of disease. It is indicated for patients with histo- and/or cytologically prov...
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Chapter
Surgical Technique and Indications for Radical Dissection: Head and Neck
The main purpose of lymphadenectomy in melanoma patients is to provide locoregional control of disease. It also plays an important role as a staging procedure. Lymph node involvement is diagnosed in different ...
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Article
Open AccessAblation of soft tissue tumours by long needle variable electrode-geometry electrochemotherapy: final report from a single-arm, single-centre phase-2 study
Standard electrochemotherapy (ECT) is effective in many tumour types but is confined to the treatment of small superficial lesions. Variable electrode-geometry ECT (VEG-ECT) may overcome these limitations by u...
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Article
Open AccessE2F1 germline copy number variations and melanoma susceptibility
Melanoma is an aggressive type of skin cancer whose aetiology remains elusive as both environmental and genetic factors can contribute to its development. Recent studies have demonstrated the existence of mult...
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Article
Growth rate and myofibroblast differentiation of desmoid fibroblast-like cells are modulated by TGF-β signaling
Desmoid-like fibromatosis (DF) is a rare myofibroblastic benign tumor, often associated with local and repeated injuries, spontaneous regression and stabilization of disease progression suggesting the involvem...
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Chapter
Management of Other Recurrent Retroperitoneal Sarcomas
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Article
Open AccessAssociations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis
Dysfunction of the circadian clock and polymorphisms of some circadian genes have been linked to cancer development and progression. We investigated the relationship between circadian genes germline variation ...
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Article
Diagnostic value of contrast-enhanced CT combined with 18-FDG PET in patients selected for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC)
Aim of the study is to assess the reliability and correlation with surgical peritoneal cancer index (PCI) of combined PET/CT and ceCT scans (PET/ceCT) performed in a session in patients with peritoneal carcin...
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Article
Open AccessCircadian pathway genetic variation and cancer risk: evidence from genome-wide association studies
Dysfunction of the circadian clock and single polymorphisms of some circadian genes have been linked to cancer susceptibility, although data are scarce and findings inconsistent. We aimed to investigate the as...
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Reference Work Entry In depth
Electrochemotherapy for Superficially Metastatic Melanoma
Cutaneous metastases are not unusual in the clinical course of malignant melanoma, occurring in 2–20% of patients, depending on primary tumor features and disease stage. Patients with superficially metastatic ...
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Article
Prognostic Role of Multiple Lymphatic Basin Drainage in Sentinel Lymph Node-Negative Trunk Melanoma Patients: A Multicenter Study from the Italian Melanoma Intergroup
Multiple lymphatic basin drainage (MLBD) is frequently observed in patients with trunk melanoma undergoing sentinel lymph node (SLN) biopsy. Conflicting data regarding the prognostic association of MLBD in SLN...
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Article
Open AccessAdjuvant chemotherapy for soft tissue sarcomas: a 10-year mono-institutional experience
The role of adjuvant chemotherapy (ACT) for soft tissue sarcomas (STS) is not standard practice. We investigated effectiveness and tolerability of ACT in patients (pts) with operated high-risk STS in clinical ...
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Living Reference Work Entry In depth
Electrochemotherapy for Superficially Metastatic Melanoma
Cutaneous metastases are not unusual in the clinical course of malignant melanoma, occurring in 2–20 % of patients, depending on primary tumor features and disease stage. Patients with superficially metastatic...
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Article
Core needle biopsy of soft tissue tumors, CEUS vs US guided: a pilot study
The purpose of this study was to evaluate the usefulness of contrast-enhanced ultrasonography (CEUS) in the bioptic sampling of soft tissue tumors (STT) compared with unenhanced ultrasonography alone.