52 Result(s)
within
Cai **ang
Science, Humanities and Social Sciences, multidisciplinary
English
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Article
Open AccessInitiating PeriCBD to probe perinatal influences on neurodevelopment during 3–10 years in China
Adverse perinatal factors can interfere with the normal development of the brain, potentially resulting in long-term effects on the comprehensive development of children. Presently, the understanding of cognit...
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Article
Open AccessStructural bases of inhibitory mechanism of CaV1.2 channel inhibitors
The voltage-gated calcium channel CaV1.2 is essential for cardiac and vessel smooth muscle contractility and brain function. Accumulating evidence demonstrates that malfunctions of CaV1.2 are involved in brain an...
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Article
Open AccessA midbrain GABAergic circuit constrains wakefulness in a mouse model of stress
Enhancement of wakefulness is a prerequisite for adaptive behaviors to cope with acute stress, but hyperarousal is associated with impaired behavioral performance. Although the neural circuitries promoting wak...
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Article
Open AccessSelective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma
Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However, we are currently unaware of any studies using selective and potent ClpP activators in lung squamous cell carcinoma. In ...
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Article
Open AccessCombining Fe nanoparticles and pyrrole-type Fe-N4 sites on less-oxygenated carbon supports for electrochemical CO2 reduction
A great challenge for electrochemical CO2 reduction is to improve energy efficiency, which requires reducing overpotential while increasing product Faraday efficiency. Here, we designedly synthesize a hybrid elec...
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Article
Open AccessFc-competent multispecific PDL-1/TIGIT/LAG-3 antibodies potentiate superior anti-tumor T cell response
The landscape of current cancer immunotherapy is dominated by antibodies targeting PD-1/PD-L1 and CTLA-4 that have transformed cancer therapy, yet their efficacy is limited by primary and acquired resistance. ...
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Article
Open AccessStructural insights into the human niacin receptor HCA2-Gi signalling complex
The hydroxycarboxylic acid receptor 2 (HCA2) agonist niacin has been used as treatment for dyslipidemia for several decades albeit with skin flushing as a common side-effect in treated individuals. Extensive e...
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Article
Open AccessVirtual elastography ultrasound via generative adversarial network for breast cancer diagnosis
Elastography ultrasound (EUS) imaging is a vital ultrasound imaging modality. The current use of EUS faces many challenges, such as vulnerability to subjective manipulation, echo signal attenuation, and unknow...
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Article
Open AccessMolecular insights into the gating mechanisms of voltage-gated calcium channel CaV2.3
High-voltage-activated R-type CaV2.3 channel plays pivotal roles in many physiological activities and is implicated in epilepsy, convulsions, and other neurodevelopmental impairments. Here, we determine the high-...
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Article
Open AccessAnti-infective therapy using species-specific activators of Staphylococcus aureus ClpP
The emergence of methicillin-resistant Staphylococcus aureus isolates highlights the urgent need to develop more antibiotics. ClpP is a highly conserved protease regulated by ATPases in bacteria and in mitochondr...
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Article
Open AccessStructural basis for modulation of human NaV1.3 by clinical drug and selective antagonist
Voltage-gated sodium (NaV) channels play fundamental roles in initiating and propagating action potentials. NaV1.3 is involved in numerous physiological processes including neuronal development, hormone secretion...
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Article
Open AccessStandard (3, 5)-threshold quantum secret sharing by maximally entangled 6-qubit states
In this paper, a standard (3, 5)-threshold quantum secret sharing scheme is presented, in which any three of five participants can resume cooperatively the classical secret from the dealer, but one or two shar...
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Article
Kainate receptor modulation by NETO2
Glutamate-gated kainate receptors are ubiquitous in the central nervous system of vertebrates, mediate synaptic transmission at the postsynapse and modulate transmitter release at the presynapse1–7. In the brain,...
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Article
Open AccessLarge scale self-assembly of plasmonic nanoparticles on deformed graphene templates
Hierarchical heterostructures of two-dimensional (2D) nanomaterials are versatile platforms for nanoscale optoelectronics. Further coupling of these 2D materials with plasmonic nanostructures, especially in no...
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Article
Open AccessDual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer
Driver genes with a mutually exclusive mutation pattern across tumor genomes are thought to have overlap** roles in tumorigenesis. In contrast, we show here that mutually exclusive prostate cancer driver alt...
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Open AccessThree-party quantum private computation of cardinalities of set intersection and union based on GHZ states
Private Set Intersection Cardinality (PSI-CA) and Private Set Union Cardinality (PSU-CA) are two cryptographic primitives whereby two or more parties are able to obtain the cardinalities of the intersection an...
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Article
Open AccessLymph node metastasis prediction of papillary thyroid carcinoma based on transfer learning radiomics
Non-invasive assessment of the risk of lymph node metastasis (LNM) in patients with papillary thyroid carcinoma (PTC) is of great value for the treatment option selection. The purpose of this paper is to devel...
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Article
Open AccessInterlayer gap widened α-phase molybdenum trioxide as high-rate anodes for dual-ion-intercalation energy storage devices
Employing high-rate ion-intercalation electrodes represents a feasible way to mitigate the inherent trade-off between energy density and power density for electrochemical energy storage devices, but efficient ...
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Article
Open AccessAuthor Correction: Triple-negative invasive breast carcinoma: the association between the sonographic appearances with clinicopathological feature
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessNew Fair Multiparty Quantum Key Agreement Secure against Collusive Attacks
Fairness is an important standard needed to be considered in a secure quantum key agreement (QKA) protocol. However, it found that most of the quantum key agreement protocols in the travelling model are not fa...
