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Article
Benzodiazepines in the brain
Great progress has been made in the last 5 yr in demonstrating the presence of benzodiazepines (BDZs) in mammalian tissues, in beginning studies on the origin of these natural compounds, and in elucidating the...
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Article
Risk factors for nosocomial bacteremia due to methicillin-resistantStaphylococcus aureus
In a prospective surveillance study (February 1990–December 1991) performed at a 1000-bed teaching hospital to identify risk factors for nosocomial methicillin-resistantStaphylococcus aureus (MRSA) bacteremia, 30...
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Article
Alcohol consumption in a rural area of Cantabria
A two-stage cross-sectional survey was performed in a representative rural sample of the autonomous community of Cantabria, to investigate the social, medical and psychopathological factors associated with alc...
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Article
Changes in alginate molecular mass distributions, broth viscosity and morphology of Azotobacter vinelandii cultured in shake flasks
The effect of different aeration conditions during the culture of Azotobacter vinelandii on the production and molecular mass of alginate was evaluated in shake flasks. In baffled flasks, the bacteria grew faste...
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Article
Clinical and epidemiological findings in mechanically-ventilated patients with methicillin-resistantStaphylococcus aureus pneumonia
Over the 5-year period from 1990 to 1994, a prospective cohort study was conducted to define the clinical and epidemiological characteristics of ventilator-associated methicillin-resistantStaphylococcus aureus (M...
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Article
Kinetics of Na+-, K+-ATPase Inhibition by an Endogenous Modulator (II-A)
We have previously reported the isolation by gel filtration and anionic exchange HPLC of two brain Na+, K+-ATPase inhibitors, II-A and II-E, and kinetics of enzyme interaction with the latter. In the present stud...
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Article
An Endogenous Na+, K+-ATPase Inhibitor Enhances Phosphoinositide Hydrolysis in Neonatal but Not in Adult Rat Brain Cortex
The effect of an endogenous Na+, K+-ATPase inhibitor, termed endobain E, on phosphoinositide hydrolysis was studied in rat brain cortical prisms and compared with that of ouabain. As already shown for ouabain, a ...
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Article
Alginate production by Azotobacter vinelandii mutants altered in poly-β-hydroxybutyrate and alginate biosynthesis
Mutant AT268 of Azotobacter vinelandii — showing diminished production of poly-β-hydroxybutyrate (PHB) due to a mutation in phbR (the gene coding for the transcriptional activator of the phbBAC biosynthetic opero...
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Article
A Comparative Study Between a Brain Na+,K+-ATPase Inhibitor (Endobain E) and Ascorbic Acid
In the search of Na+,K+-ATPase modulators, we have reported the isolation by gel filtration and HPLC of a brain fraction, termed endobain E, which highly inhibits Na+,K+-ATPase activity. In the present study we c...
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Article
The Effect of Endogenous Modulator Endobain E on NMDA Receptor Is Interfered by Zn22+ but Is Independent of Modulation by Spermidine
A brain endogenous factor, termed endobain E, allosterically decreases [3H]dizocilpine binding to NMDA receptor. Such effect depends on receptor activation by the coagonists glutamate and glycine and is interfere...
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Article
Open AccessPhase II trial of cisplatin and capecitabine in patients with squamous cell carcinoma of the head and neck, and correlative study of angiogenic factors
The combination of cisplatin and capecitabine was evaluated in patients with recurrent or unresectable squamous cell carcinoma of the head and neck (HNSCC), and outcome parameters were correlated with the expr...
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Article
Modulation of Aspartate Release by Ascorbic Acid and Endobain E, an Endogenous Na+, K+-ATPase Inhibitor
The isolation of a soluble brain fraction which behaves as an endogenous ouabain-like substance, termed endobain E, has been described. Endobain E contains two Na+, K+-ATPase inhibitors, one of them identical to ...
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Article
Coronary occlusions in first non-ST segment elevation myocardial infarction
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Article
Acute pulmonary edema with preserved ejection fraction: clinical and prognostic profile in patients with coronary heart disease
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Temporal trends in the type of recurrent acute coronary syndrome
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Article
The oxygen transfer rate influences the molecular mass of the alginate produced by Azotobacter vinelandii
The influence of oxygen transfer rate (OTR) on the molecular mass of alginate was studied. In batch cultures without dissolved oxygen tension (DOT) control and at different agitation rates, the DOT was nearly ...
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Article
DICKKOPF-4 is induced by TCF/β-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1α,25-dihydroxyvitamin D3
Aberrant activation of the Wnt/β-catenin signaling pathway is a hallmark of colon cancer. We show that the Wnt antagonist DICKKOPF-4 (DKK-4) gene is repressed by 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) in human c...
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Article
Oral and Poster Papers Submitted for Presentation at the 5th Congress of the EUGMS “Geriatric Medicine in a Time of Generational Shift September 3–6, 2008 Copenhagen, Denmark
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Article
Mimosa and chestnut tannin extracts reacted with hexamine in solution
Autocondensation reactions of mimosa and chestnut tannin extracts solutions have been analysed at several pH by differential scanning calorimetry (DSC). Alkaline pH promotes autocondensation reaction of these ...
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Article
Carbapenem-resistant Pseudomonas aeruginosa: factors influencing multidrug-resistant acquisition in non-critically ill patients
A cohort study was carried out on hospitalized adult non-critically ill patients (January 2003–December 2004) to identify factors associated with the acquisition of multidrug-resistant Pseudomonas aeruginosa (MDR...
