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  1. No Access

    Article

    DICKKOPF-4 is induced by TCF/β-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1α,25-dihydroxyvitamin D3

    Aberrant activation of the Wnt/β-catenin signaling pathway is a hallmark of colon cancer. We show that the Wnt antagonist DICKKOPF-4 (DKK-4) gene is repressed by 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) in human c...

    N Pendás-Franco, J M García, C Peña, N Valle, H G Pálmer, M Heinäniemi… in Oncogene (2008)

  2. No Access

    Article

    SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue

    SNAI1, ZEB1, E-cadherin (CDH1), and vitamin D receptor (VDR) genes regulate the epithelial–mesenchymal transition (EMT) that initiates the invasion process of many tumor cells. We hypothesized that this process c...

    C Peña, J M García, M J Larriba, R Barderas, I Gómez, M Herrera, V García… in Oncogene (2009)

  3. No Access

    Article

    E2f3 in tumor macrophages promotes lung metastasis

    The Rb-E2F axis is an important pathway involved in cell-cycle control that is deregulated in a number of cancers. E2f transcription factors have distinct roles in the control of cell proliferation, cell survi...

    P Trikha, N Sharma, C Pena, A Reyes, T Pécot, S Khurshid, M Rawahneh, J Moffitt… in Oncogene (2016)

  4. No Access

    Article

    Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI)

    The transcription factor Twist1 is involved in the epithelial–mesenchymal transition and contributes to cancer metastasis through mostly unknown mechanisms. In colorectal cancer, Twist1 expression is mainly re...

    I García-Palmero, S Torres, R A Bartolomé, A Peláez-García, M J Larriba… in Oncogene (2016)