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  1. No Access

    Article

    Endocrine, pharmacokinetic and clinical studies of the aromatase inhibitor 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione ('pyridoglutethimide') in postmenopausal breast cancer patients

    The aromatase inhibitor, 'pyridoglutethimide' (PyG), has been shown previously to suppress serum oestrogen levels in postmenopausal breast cancer patients and to achieve clinical responses at a dose of 500 mg ...

    M Dowsett, F MacNeill, A Mehta, C Newton, B Haynes, A Jones… in British Journal of Cancer (1991)

  2. Article

    Open Access

    Enhanced repair of DNA interstrand crosslinking in ovarian cancer cells from patients following treatment with platinum-based chemotherapy

    Despite high tumour response rates to platinum-based chemotherapy in ovarian cancer survival is poor due to the emergence of drug resistance. Mechanistic studies in clinical material have been hampered by the ...

    P Wynne, C Newton, J A Ledermann, A Olaitan, T A Mould… in British Journal of Cancer (2007)

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