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  1. No Access

    Article

    Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails

    Prostate cancer is one of the major causes of cancer-related death in the western world. Androgen-deprivation therapy (ADT) for the suppression of androgens binding to the androgen receptor (AR) has been the n...

    Y Niu, T-M Chang, S Yeh, W-L Ma, Y Z Wang, C Chang in Oncogene (2010)

  2. Article

    Open Access

    P02.34. Therapeutic effects of traditional Chinese medicine in cancer patients undergoing chemotherapy or radiotherapy: randomized, double-blind controlled trial

    L Lo, C Chen, C Chang, T Lee, M Hou, T Cheng… in BMC Complementary and Alternative Medicine (2012)

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  3. No Access

    Article

    Integrative Medicine as Adjunct Therapy in the Treatment of Atopic Dermatitis—the Role of Traditional Chinese Medicine, Dietary Supplements, and Other Modalities

    Atopic dermatitis (AD) is becoming increasingly prevalent in the pediatric population, with rates reportedly as high as 18–25 %. Westernized medicine has traditionally used a combination of emollients, antihis...

    C. DiNicola, A. Kekevian, C. Chang in Clinical Reviews in Allergy & Immunology (2013)

  4. No Access

    Article

    Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling

    Although the contribution of the bone marrow mesenchymal stem cells (BM-MSCs) in cancer progression is emerging, their potential roles in prostate cancer (PCa) remain unclear. Here, we showed that PCa cells co...

    J Luo, S Ok Lee, L Liang, C-K Huang, L Li, S Wen, C Chang in Oncogene (2014)

  5. No Access

    Article

    Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver

    The androgen receptor (AR) is expressed in many cell types and the androgen/AR signaling has been found to have important roles in modulating tumorigenesis and metastasis in several cancers including prostate,...

    C Chang, S O Lee, S Yeh, T M Chang in Oncogene (2014)

  6. No Access

    Article

    IMP3 promotes stem-like properties in triple-negative breast cancer by regulating SLUG

    IMP3 (insulin-like growth factor-2 mRNA binding protein 3) is an oncofetal protein whose expression is prognostic for poor outcome in several cancers. Although IMP3 is expressed preferentially in triple-negati...

    S Samanta, H Sun, H L Goel, B Pursell, C Chang, A Khan, D L Greiner, S Cao… in Oncogene (2016)

  7. No Access

    Article

    Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia

    It is well established that hypoxia contributes to tumor progression in a hypoxia inducible factor-2α (HIF-2α)-dependent manner in renal cell carcinoma (RCC), yet the role of long noncoding RNAs (LncRNAs) invo...

    W Zhai, Y Sun, M Jiang, M Wang, T A Gasiewicz, J Zheng, C Chang in Oncogene (2016)

  8. No Access

    Article

    Neuroendocrine prostate cancer (NEPCa) increased the neighboring PCa chemoresistance via altering the PTHrP/p38/Hsp27/androgen receptor (AR)/p21 signals

    Prostatic neuroendocrine cells (NE) are an integral part of prostate cancer (PCa) and are associated with PCa progression. As the current androgen deprivation therapy with anti-androgens may promote the neuroe...

    Y Cui, Y Sun, S Hu, J Luo, L Li, X Li, S Yeh, J **, C Chang in Oncogene (2016)

  9. No Access

    Article

    Androgen receptor promotes melanoma metastasis via altering the miRNA-539-3p/USP13/MITF/AXL signals

    Early studies demonstrated that male melanoma patients have worse survival than female patients, yet the detailed mechanisms for this gender difference remain unclear. We analyzed around 100 cases of human mel...

    Y Wang, Z Ou, Y Sun, S Yeh, X Wang, J Long, C Chang in Oncogene (2017)

  10. Article

    Erratum: Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2α/C-MYC axis under hypoxia

    Correction to: Oncogene (2016) 35, 4866–4880; doi:10.1038/onc.2016.19; published online 14 March 2016 Since the online publication of this article, the authors have found that, during an internal quality contr...

    W Zhai, Y Sun, M Jiang, M Wang, T A Gasiewicz, J Zheng, C Chang in Oncogene (2017)

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  11. No Access

    Article

    A regulatory circuit HP1γ/miR-451a/c-Myc promotes prostate cancer progression

    Heterochromatin protein 1γ (HP1γ) has been implicated in carcinogenesis of various cancer types. However, the role of HP1γ in prostate cancer (PCa) progression and the underlying molecular mechanisms remain la...

    C Chang, J Liu, W He, M Qu, X Huang, Y Deng, L Shen, X Zhao, H Guo, J Jiang… in Oncogene (2018)