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  1. Article

    Open Access

    Clinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia

    Suppressor of cytokine signaling 1 (SOCS1) protein, which encodes a member of signal transducers and activators of transcription-induced inhibitors, takes part in a negative regulation of cytokine signaling. T...

    H-A Hou, J-W Lu, T-Y Lin, C-H Tsai, W-C Chou, C-C Lin, Y-Y Kuo… in Blood Cancer Journal (2017)

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  2. No Access

    Article

    Integrated Drug Expression Analysis for leukemia: an integrated in silico and in vivo approach to drug discovery

    Screening for drug compounds that exhibit therapeutic properties in the treatment of various diseases remains a challenge even after considerable advancements in biomedical research. Here, we introduce an inte...

    M H Ung, C-H Sun, C-W Weng, C-C Huang, C-C Lin, C-C Liu… in The Pharmacogenomics Journal (2017)

  3. Article

    The impact of global budgeting on health service utilization, health care expenditures, and quality of care among patients with pneumonia in Taiwan

    This study evaluated the effect of global budgeting on health service utilization, health care expenditures, and the quality of care among patients with pneumonia in Taiwan. The National Health Insurance Resea...

    C.-Y. Lin, T. Ma, C.-C. Lin, C.-H. Kao in European Journal of Clinical Microbiology … (2016)

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  4. Article

    Open Access

    Randomised controlled trial on the effectiveness of home-based walking exercise on anxiety, depression and cancer-related symptoms in patients with lung cancer

    Although exercise has been addressed as an adjuvant treatment for anxiety, depression and cancer-related symptoms, limited studies have evaluated the effectiveness of exercise in patients with lung cancer.

    H-M Chen, C-M Tsai, Y-C Wu, K-C Lin, C-C Lin in British Journal of Cancer (2015)

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  5. No Access

    Article

    Tumor-specific suicide gene therapy for hepatocellular carcinoma by transcriptionally targeted retroviral replicating vectors

    Replicating virus vectors are attractive tools for anticancer gene therapy, but the potential for adverse events due to uncontrolled spread of the vectors has been a major concern. To design a tumor-specific r...

    Y-H Lai, C-C Lin, S-H Chen, C-K Tai in Gene Therapy (2015)

  6. Article

    Open Access

    Independent and joint effect of type 2 diabetes and gastric and hepatobiliary diseases on risk of pancreatic cancer risk: 10-year follow-up of population-based cohort

    Type 2 diabetes mellitus, gastric and hepatobiliary comorbidities, and cancer share common risk factors: for example, tobacco, obesity, physical inactivity, high calorie intake, and metabolic disorders. Prior ...

    C-C Lin, J-H Chiang, C-I Li, T-F Hsieh, C-S Liu, W-Y Lin… in British Journal of Cancer (2014)

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  7. Article

    Open Access

    A phase I study of two dosing schedules of volasertib (BI 6727), an intravenous polo-like kinase inhibitor, in patients with advanced solid malignancies

    Polo-like kinase 1 (Plk1) has an important role in mitosis. Volasertib (BI 6727), a potent and selective cell cycle kinase inhibitor, induces mitotic arrest and apoptosis by targeting Plk; this phase I study s...

    C-C Lin, W-C Su, C-J Yen, C-H Hsu, W-P Su, K-H Yeh, Y-S Lu… in British Journal of Cancer (2014)

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  8. No Access

    Article

    An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA

    Histone deacetylase (HDAC) inhibitors are used in treating certain human malignancies. Our laboratories demonstrated their capability in enhancing antitumor effect of DNA vaccine driven by an RNA polymerase II...

    M-C Yen, T-Y Weng, Y-L Chen, C-C Lin, C-Y Chen, C-Y Wang, H-L Chao… in Cancer Gene Therapy (2013)

  9. Article

    Open Access

    Basal core promoter mutation is associated with progression to cirrhosis rather than hepatocellular carcinoma in chronic hepatitis B virus infection

    As most cases of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) have concurrent cirrhosis, viral factors identified to be associated with HCC might be related to cirrhosis rather than HCC.

    C-M Chu, C-C Lin, Y-C Chen, W-J Jeng, S-M Lin, Y-F Liaw in British Journal of Cancer (2012)

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  10. No Access

    Article

    RNA interference-mediated silencing of Foxo3 in antigen-presenting cells as a strategy for the enhancement of DNA vaccine potency

    The transcription factor Forkhead box O3 (Foxo3) has a critical role in suppressing the expansion of antigen-specific effector T-cell populations; hence, Foxo3 is a potential target for enhancing the antitumor...

    S-T Wang, C-C Chang, M-C Yen, C-F Tu, C-L Chu, Y-T Peng, D-Y Chen, J-L Lan… in Gene Therapy (2011)

  11. Article

    Open Access

    A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients

    Human hepatocellular carcinoma (HCC) cells are largely deficient of argininosuccinate synthetase and thus auxotrophic for arginine. This study aims to investigate the efficacy and pharmacodynamics of pegylated...

    T-S Yang, S-N Lu, Y Chao, I-S Sheen, C-C Lin, T-E Wang… in British Journal of Cancer (2010)

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  12. No Access

    Article

    An HDAC inhibitor enhances the antitumor activity of a CMV promoter-driven DNA vaccine

    The cytomegalovirus (CMV) promoter is considered to be one of the strongest promoters for driving the in vivo expression of genes encoded by DNA vaccines. However, the efficacy of DNA vaccines has so far been dis...

    M-D Lai, C-S Chen, C-R Yang, S-Y Yuan, J-J Tsai, C-F Tu, C-C Wang… in Cancer Gene Therapy (2010)

  13. Article

    Open Access

    Angiotensin-converting enzyme gene insertion/deletion polymorphism is associated with risk of oral precancerous lesion in betel quid chewers

    To investigate whether angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism is related to the risk of oral precancerous lesions (OPL) in Taiwanese subjects who chew betel quid, a total o...

    F-M Chung, Y-H Yang, C-H Chen, C-C Lin, T-Y Shieh in British Journal of Cancer (2005)

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  14. No Access

    Article

    Automatic optimum order selection of parametric modelling for the evaluation of abnormal intra-QRS signals in signal-averaged electrocardiograms

    Abnormal intra-QRS potentials (AIQPs) in signal-averaged electrocardiograms have been proposed as a risk evaluation index for ventricular arrhythmias. The purpose of the paper was to develop an automatic algor...

    C. -C. Lin, C. -M. Chen, I. -F. Yang… in Medical and Biological Engineering and Com… (2005)

  15. No Access

    Article

    Human centromeric DNAs

    Human centromeres have been extensively studied over the past two decades. Consequently, more is known of centromere structure and organization in humans than in any other higher eukaryote species. Recent adv...

    C. Lee, R. Wevrick, R. B. Fisher, M. A. Ferguson-Smith, C. C. Lin in Human Genetics (1997)

  16. No Access

    Article

    Conserved Structure and Adjacent Location of the Thrombin Receptor and Protease-Activated Receptor 2 Genes Define a Protease-Activated Receptor Gene Cluster

    Thrombin is a serine protease that elicits a variety of cellular responses. Molecular cloning of a thrombin receptor revealed a G protein-coupled receptor that is activated by a novel proteolytic mechanism. Re...

    Mark Kahn, Kenji Ishii, Wen-Lin Kuo, Michael Piper, Andrew Connolly… in Molecular Medicine (1996)

  17. No Access

    Article

    The skin, tongue, and brain as favorable organs for hog cholera diagnosis by immunofluorescence

    Hog cholera virus antigens were found densely distributed in skin and tongue of pigs experimentally infected with hog cholera virus. The finding described here warrants the usage of ear biopsies for hog choler...

    I. C. Pan, T. S. Huang, C. H. Pan, Shenq-Yi Chern, Shu-Hwae Lee… in Archives of Virology (1993)

  18. No Access

    Article

    Familial paracentric inversions inv(2)(q31q35) and inv(8)(q22.3q24.13) ascertained through reproductive abnormalities

    Two cases of familial paracentric inversion, one in the long arm of chromosome 2 and the other in the long arm of chromosome 8, are described. The first was ascertained in a woman who was studied because of re...

    C. C. Lin, P. Bowen, J. J. Hoo in Human Genetics (1987)

  19. No Access

    Article

    Fragile sites and structural rearrangements in cancer

    We retracted information from a computerized databank which contains the cytogenetic findings of 17,000 patients with leukemia and lymphoma. Cytogenetic data from patients with solid tumors were compiled from ...

    M. De Braekeleer, B. Smith, C. C. Lin in Human Genetics (1985)

  20. No Access

    Article

    A de novo case of trisomy 10p: Gene dosage studies of hexokinase, inorganic pyrophosphatase and adenosine kinase

    A female infant with multiple congenital anomalies is presented. Cytogenetic study revealed the presence of a de novo, supernumerary, small telocentric chromosome exhibiting the banding pattern of the short ar...

    F. F. Snyder, C. C. Lin, N. L. Rudd, J. E. Shearer, E. M. Heikkila… in Human Genetics (1984)

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