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Article
Non-ketotic hyperglycaemia-related paroxysmal bilateral hand paraesthesia misdiagnosed as diabetic neuropathy
Non-ketotic hyperglycaemia (NKH)-related partial seizure disorders are not uncommon in clinical practice but still deserve attention as they significantly affect neurologic outcome if unnoticed. The atypical p...
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Article
Major brain lesions detected on sonographic screening of apparently normal term neonates
Major congenital or acquired structural abnormalities of the brain, with significant prognostic implications have rarely been emphasised in apparently normal infants. Our purpose was to investigate the prevale...
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Article
High-resolution cranial ultrasound in the shaken-baby syndrome
With limited near-field resolution and accessible acoustic windows, sonography has not been advocated for assessing central nervous system injuries in the shaken-baby syndrome. Our purpose was to correlate hi...
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Article
MRI in acute neuropathic Gaucher's disease
We present the cranial MRI findings in a 6-month-old girl with biopsy-proven acute neuropathic Gaucher's disease, which include unilateral cerebral atrophy and dural thickening with contrast enhancement.
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Article
Middle ear catalase distribution in an animal model of otitis media
Increasing evidence implicates free radicals in the pathogenesis of inflammatory disease, including otitis media. The anti-oxidant enzymes catalase, glutathione peroxidase and superoxide dismutase protect tiss...
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Article
Mediation of signal transduction in keratinocytes of human middle ear cholesteatoma byras protein
Immunolocalization was used to investigate the distribution of ras protein in both congenital and acquired cholesteatoma tissues. A pathological feature of middle ear cholesteatoma included accumulation of kerati...
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Article
Localization of intercellular adhesion molecule-1 in middle ear cholesteatoma
Intercellular adhesion molecule-1 (ICAM-1) may have a role in acquired cholesteatoma, which is usually associated with an inflammatory reaction occurring in the middle ear cavity. The presence of ICAM-1 in hum...
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Article
Superoxide dismutase in an animal model of otitis media
Cu, Zn superoxide dismutase (SOD) is a metalloprotein that catalyzes the dismutation of the superoxide anion into O2 − and H202, and therefore functions to maintain a low intracellular concentration of an otherwi...
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Article
Immunohistochemical studies of sensory neurons in rat olfactory epithelium
The olfactory sensory neurons undergo continuous turnover under normal physiological conditions. Injured olfactory sensory neurons are also replaceable. In this study, we investigated cellular differentiation ...
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Article
Platelet-derived growth factor in middle ear cholesteatoma
Platelet-derived growth factor (PDGF) was localized in human middle ear cholesteatoma tissue by an immunoperoxidase technique using rabbit anti-human PDGF IgG. PDGF was found mainly in basal cells and in granu...
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Article
Langerhans cells in human middle ear cholesteatomas
Langerhans cells have been found in cholesteatomas for many years. It is believed that they are immunocompetent cells and have the same role in cell-mediated immunologic mechanisms in cholesteatoma as well as ...
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Article
An immunocytochemical study of cytokeratin expression in human middle ear cholesteatoma
An indirect immunofluorescent method with monoclonal anti-cytokeratin antibodies was used to localize various cytokeratins in human middle ear cholesteatoma. The 50 K/58 K and 56.5 K/65–67 K paired cytokeratin...
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Article
Effects of granulation tissue conditioned medium on the in vitro differentiation of keratinocytes
The accumulation of desquamated keratinizing squamous epithelial cells appears to be a crucial factor in the pathogenesis of middle ear cholesteatomas. The accumulation of keratin debris is due to the prolifer...
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Article
Localization of fibronectin in human middle ear cholesteatoma
Fibronectin was localized in human cholesteatoma tissues by immunohistochemical methods. The avidin-biotin-peroxidase complex staining method was used with specific fibronectin antibody. Fibronectin appeared t...
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Article
The effect of endotoxin and prostaglandin E2 on the proliferation of keratinocytes in vitro
Since the rate of epidermal basal cell proliferation appears to be a crucial factor in the development of acquired cholesteatoma, we studied the effect of prostaglandin E2 (PGE2) and endotoxin on the growth of...