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    Article

    Endospanin 1 silencing in the hypothalamic arcuate nucleus contributes to sustained weight loss of high fat diet obese mice

    Leptin targets specific receptors (OB-R) expressed in the hypothalamus to regulate energy balance. Leptin decreases food intake in normal weight individuals, but this effect is blunted in obese subjects who ar...

    V Vauthier, T D Swartz, P Chen, C Roujeau, M Pagnon, J Mallet, C Sarkis… in Gene Therapy (2014)