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Article
An invariant Trypanosoma vivax vaccine antigen induces protective immunity
Trypanosomes are protozoan parasites that cause infectious diseases, including African trypanosomiasis (slee** sickness) in humans and nagana in economically important livestock1,2. An effective vaccine against...
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Protocol
Cloning of Recombinant Monoclonal Antibodies from Hybridomas in a Single Mammalian Expression Plasmid
Antibodies are an integral part of biological and medical research. In addition, immunoglobulins are used in many diagnostic tests and are becoming increasingly important in the therapy of diseases. To express...
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Article
Correction: Corrigendum: The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
Nature Communications 2: Article number: 601 (2011); Published: 20 December 2011; Updated: 19 September 2013. In the Methods section of this Article, the species of the tissue plasminogen activator secretory s...
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Article
The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody
Current vaccine strategies against the asexual blood stage of Plasmodium falciparum are mostly focused on well-studied merozoite antigens that induce immune responses after natural exposure, but have yet to induc...
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Article
Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
The ability to prevent or impair the invasion of erythrocytes by the Plasmodium falciparum merozoite, the initial blood stage of malaria infection, has long been an ambition for those working on antimalarial ther...
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Article
Open AccessA rapid and scalable method for selecting recombinant mouse monoclonal antibodies
Monoclonal antibodies with high affinity and selectivity that work on wholemount fixed tissues are valuable reagents to the cell and developmental biologist, and yet isolating them remains a long and unpredict...
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Article
Organizing cell renewal in the intestine: stem cells, signals and combinatorial control
The epithelial lining of the intestine renews itself more rapidly than any other tissue in the vertebrate body, replacing the entire population of differentiat...
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Article
Expression of mutant JAGGED1 alleles in patients with Alagille syndrome
Heterozygous mutations in JAGGED1 (JAG1), encoding a ligand for Notch receptors, have been identified in patients with Alagille syndrome (AGS). These mutations map to the extracellular and transmembrane domains o...