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    Insights into noncanonical E1 enzyme activation from the structure of autophagic E1 Atg7 with Atg8

    The mechanism by which the noncanonical E1-like enzyme Atg7 activates ubiquitin-like Atg8 to trigger autophagy has not been well understood. The crystal structures of the N-terminal domain of Atg7 alone and C-...

    Seung Beom Hong, Byeong-Won Kim, Kyung-Eun Lee… in Nature Structural & Molecular Biology (2011)