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Open AccessAuthor Correction: Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients
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Open AccessImmunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection
Safe and effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are based on a mutated version of the ...
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Open AccessMale genitourinary schistosomiasis-related symptoms among long-term Western African migrants in Spain: a prospective population-based screening study
Schistosomiasis is highly endemic in sub-Saharan Africa and frequently imported to Europe. Male urogenital manifestations are often neglected. We aimed to ascertain the prevalence of genitourinary clinical sig...
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Open AccessImmunisation efficacy of a stabilised SARS-CoV-2 spike glycoprotein in two geriatric animal models
Age is associated with reduced efficacy of vaccines and linked to higher risk of severe COVID-19. Here we determined the impact of ageing on the efficacy of a SARS-CoV-2 vaccine based on a stabilised Spike gly...
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Open AccessSAMHD1 expression is a surrogate marker of immune infiltration and determines prognosis after neoadjuvant chemotherapy in early breast cancer
The lack of validated surrogate biomarkers is still an unmet clinical need in the management of early breast cancer cases that do not achieve complete pathological response after neoadjuvant chemotherapy (NACT...
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Open AccessVirus-like particle-mediated delivery of structure-selected neoantigens demonstrates immunogenicity and antitumoral activity in mice
Neoantigens are patient- and tumor-specific peptides that arise from somatic mutations. They stand as promising targets for personalized therapeutic cancer vaccines. The identification process for neoantigens ...
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Open AccessSelf-sampling monkeypox virus testing in high-risk populations, asymptomatic or with unrecognized Mpox, in Spain
The recent monkeypox virus (MPXV) outbreak was of global concern and has mainly affected gay, bisexual and other men who have sex with men (GBMSM). Here we assess prevalence of MPXV in high-risk populations of...
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Open AccessSafety and immunogenicity of a recombinant protein RBD fusion heterodimer vaccine against SARS-CoV-2
In response to COVID-19 pandemic, we have launched a vaccine development program against SARS-CoV-2. Here we report the safety, tolerability, and immunogenicity of a recombinant protein RBD fusion heterodimeri...
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Open AccessAlanine-based spacers promote an efficient antigen processing and presentation in neoantigen polypeptide vaccines
Neoantigens are tumor-specific antigens that are mostly particular for each patient. Since the immune system is able to mount a specific immune response against these neoantigens, they are a promising tool for...
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Open AccessAn engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses
Antigen display on the surface of Virus-Like Particles (VLPs) improves immunogenicity compared to soluble proteins. We hypothesised that immune responses can be further improved by increasing the antigen densi...
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Open AccessAuthor Correction: Modulation of the autophagic pathway inhibits HIV-1 infection in human lymphoid tissue cultured ex vivo
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Open AccessIdentifying the needs of older people living with HIV (≥ 50 years old) from multiple centres over the world: a descriptive analysis
Older People Living with HIV (OPWH) combine both aging and HIV-infection features, resulting in ageism, stigma, social isolation, and low quality of life. This context brings up new challenges for healthcare p...
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Open AccessMonitoring SARS-CoV-2 variant transitions using differences in diagnostic cycle threshold values of target genes
Monitoring the emergence of new SARS-CoV-2 variants is important to detect potential risks of increased transmission or disease severity. We investigated the identification of SARS-CoV-2 variants from real-tim...
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Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial
HIVACAT T-cell immunogen (HTI) is a novel human immunodeficiency virus (HIV) vaccine immunogen designed to elicit cellular immune responses to HIV targets associated with viral control in humans. The AELIX-002...
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Open AccessKinetics of humoral immune response over 17 months of COVID-19 pandemic in a large cohort of healthcare workers in Spain: the ProHEpiC-19 study
Understanding the immune response to the SARS-CoV-2 virus is critical for efficient monitoring and control strategies. The ProHEpic-19 cohort provides a fine-grained description of the kinetics of antibodies a...
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Open AccessGlucocorticoids’ treatment impairs the medium-term immunogenic response to SARS-CoV-2 mRNA vaccines in Systemic Lupus Erythematosus patients
Limited data exists on SARS-CoV-2 sustained-response to vaccine in patients with rheumatic diseases. This study aims to evaluate neutralizing antibodies (nAB) induced by SARS-CoV-2 vaccine after 3 to 6 months ...
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Open AccessAuthor Correction to: SARS-CoV-2 interaction with Siglec-1 mediates trans-infection by dendritic cells
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Open AccessPrevalence of HPV-DNA and E6 mRNA in lung cancer of HIV-infected patients
HIV-infected individuals could be at a greater risk for develo** lung cancer than the general population due to the higher prevalence in the former of human papillomavirus (HPV) in the oral cavity and higher...
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Article
Open AccessProspective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients
Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitaliz...
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Article
Open AccessModulation of the autophagic pathway inhibits HIV-1 infection in human lymphoid tissue cultured ex vivo
A complex link exists between HIV-1 and autophagy, and discordant results have been reported in different in vitro models regarding the way HIV and autophagy modulate each other. Despite this, there is very li...
