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Article

Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni

Schistosomiasis is caused by parasites of the genus Schistosoma, which infect more than 200 million people. Praziquantel (PZQ) has been the main drug for controlling schistosomiasis for over four decades, but des...

Lauro Ribeiro de Souza Neto, Bogar Omar Montoya, José Brandão-Neto… in Scientific Reports (2024)