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Article
Open AccessSmooth muscle NF90 deficiency ameliorates diabetic atherosclerotic calcification in male mice via FBXW7-AGER1-AGEs axis
Hyperglycemia accelerates calcification of atherosclerotic plaques in diabetic patients, and the accumulation of advanced glycation end products (AGEs) is closely related to the atherosclerotic calcification. Her...
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Article
The alpha2-adrenergic receptor agonist clonidine protects against cerebral ischemia/reperfusion induced neuronal apoptosis in rats
Apoptosis is the crucial pathological mechanism following cerebral ischemic injury. Our previous studies demonstrated that clonidine, one agonist of alpha2-adrenergic receptor (α2-AR), could attenuate cerebral...
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Article
zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function
CD80 is a transmembrane glycoprotein belonging to the B7 family, which has emerged as a crucial molecule in T cell modulation via the CD28 or CTLA4 axes. CD80-involved regulation of immune balance is a finely ...
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Article
Hydrologic infiltration mode of completely decomposed granite slopes under the influence of gas-saturated fractures retardation and diversion
Residual fractures are an essential structural feature preserved in completely decomposed granite (CDG). However, their role in regulating rainwater infiltration and runoff remains unclear. In this study, we d...
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Article
Corrugated Graphene Paper Reinforced Silicone Resin Composite for Efficient Interface Thermal Management
With the rapid development of high-power-density electronic devices, interface thermal resistance has become a critical barrier for effective heat management in high-performance electronic products. Therefore,...
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Article
Open AccessProto-oncogene c-Myb potentiates cisplatin resistance of ovarian cancer cells by downregulating lncRNA NKILA and modulating cancer stemness and LIN28A-let7 axis
Ovarian cancer is a major gynecological cancer that has poor prognosis associated mainly to its late diagnosis. Cisplatin is an FDA approved ovarian cancer therapy and even though the therapy is initially prom...
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Article
Intermediate phase-assisted growth of CsPbBr3 for high performance of carbon-based perovskite solar cells
CsPbBr3 inorganic perovskites have been regarded as the promising materials in the field of photovoltaics because of the high tolerance against environment. The high energy barrier of phase transition from lead b...
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Article
Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis
Diabetes mellitus results in numerous complications. Diabetic pulmonary fibrosis (DPF), a late pulmonary complication of diabetes, has not attracted as much attention as diabetic nephropathy and cardiomyopathy...
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Article
Open AccessRadical innovation breakthroughs of biodegradation of plastics by insects: history, present and future perspectives
Insects damaging and penetrating plastic packaged materials has been reported since the 1950s. Radical innovation breakthroughs of plastic biodegradation have been initiated since the discovery of biodegradati...
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Article
Open AccessAbnormal threshold behaviors of photo-pion production off the proton in the GZK region
The cosmic-ray spectrum structures help to study the acceleration and propagation mechanism of ultra-high energy cosmic rays, and these structures were predicted to culminate in a cut-off, named the Greisen–Za...
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Article
Open AccessEco-environmental changes due to human activities in the Erhai Lake Basin from 1990 to 2020
Human activities have increased with urbanisation in the Erhai Lake Basin, considerably impacting its eco-environmental quality (EEQ). This study aims to reveal the evolution and driving forces of the EEQ usin...
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Article
Corrosion evaluation and resistance study of alloys in chloride salts for concentrating solar power plants
Thermal energy storage (TES) systems based on molten salt are widely used in concentrating solar power (CSP) plants. The investigation of the corrosion behavior of alloy materials in molten salt is crucial for...
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Article
Lenvatinib Versus Atezolizumab Plus Bevacizumab in the First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Meta-Analysis of Real-World Studies
Immunotherapy has revolutionized the treatment of hepatocellular carcinoma (HCC). However, whether adding immunotherapy to antiangiogenic therapy benefits patients with unresectable HCC (uHCC) more in the firs...
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Article
A 5G-based telerobotic ultrasound system provides qualified abdominal ultrasound services for patients on a rural island: a prospective and comparative study of 401 patients
To explore the feasibility of a 5G-based telerobotic ultrasound (US) system for providing qualified abdominal US services on a rural island.
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Article
Brittleness ductility transition depth of new fracture in the Baodi Miaozhuang Uplift
Today’s earthquakes are the most direct manifestation of the latest tectonic activity and are the most powerful tool to understand the characteristics of nonrigid deformation within a continent. Particularly, ...
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Article
FeSTGCN: A frequency-enhanced spatio-temporal graph convolutional network for traffic flow prediction under adaptive signal timing
Traffic flow prediction is the fundamental cornerstone of intelligent urban transportation systems. However, existing research has predominantly focused on exploring spatiotemporal dependencies within the spat...
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Article
A colorimetric sensing strategy based on chitosan-stabilized platinum nanoparticles for quick detection of α-glucosidase activity and inhibitor screening
α-Glucosidase (α-Glu) is implicated in the progression and pathogenesis of type II diabetes (T2D). In this study, we developed a rapid colorimetric technique using platinum nanoparticles stabilized by chitosan...
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Article
Robust Optimization Dispatch Method for Distribution Network Considering Four-Quadrant Power Output of Energy Storage Devices
This paper describes a technique for improving distribution network dispatch by using the four-quadrant power output of distributed energy storage systems to address voltage deviation and grid loss problems re...
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Article
Open AccessAssociations between UGT1A1, SLCO1B1, SLCO1B3, BLVRA and HMOX1 polymorphisms and susceptibility to neonatal severe hyperbilirubinemia in Chinese Han population
Severe neonatal hyperbilirubinemia could lead to kernicterus and neonatal death. This study aimed to analyze the association between single nucleotide polymorphisms in genes involved in bilirubin metabolism an...
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Article
Open AccessPhylogeny and diversification of genus Sanicula L. (Apiaceae): novel insights from plastid phylogenomic analyses
The genus Sanicula L. is a unique perennial herb that holds important medicinal values. Although the previous studies on Sanicula provided us with a good research basis, its taxonomic system and interspecific rel...
