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  1. Article

    Open Access

    Neo-intline: integrated pipeline enables neoantigen design through the in-silico presentation of T-cell epitope

    Neoantigen vaccines are one of the most effective immunotherapies for personalized tumour treatment. The current immunogen design of neoantigen vaccines is usually based on whole-genome sequencing (WGS) and bi...

    Bingyu Li, ** **g, Genhui Zheng, Chenyu Pi in Signal Transduction and Targeted Therapy (2023)

  2. Article

    Open Access

    Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease

    Interleukin 27 (IL-27), a heterodimeric cytokine composed of Epstein-Barr virus-induced 3 and p28, is a pleiotropic cytokine with both pro-and anti-inflammatory properties. However, the precise role of IL-27 i...

    Huanle Gong, Shoubao Ma, Jia Chen, Bingyu Yang in Signal Transduction and Targeted Therapy (2022)

  3. Article

    Open Access

    TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity

    Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase, which plays an essential role in both innate and adaptive immunity. However, the key molecular mechanisms that regulate SYK activity are poorly u...

    Xueer Wang, Honghai Zhang, Zhugui Shao in Signal Transduction and Targeted Therapy (2021)

  4. Article

    Open Access

    High stearic acid diet modulates gut microbiota and aggravates acute graft-versus-host disease

    Bingyu Yang, **anfeng Zhang, Huanle Gong in Signal Transduction and Targeted Therapy (2021)