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Article
Open AccessNeo-intline: integrated pipeline enables neoantigen design through the in-silico presentation of T-cell epitope
Neoantigen vaccines are one of the most effective immunotherapies for personalized tumour treatment. The current immunogen design of neoantigen vaccines is usually based on whole-genome sequencing (WGS) and bi...
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Article
Open AccessDendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease
Interleukin 27 (IL-27), a heterodimeric cytokine composed of Epstein-Barr virus-induced 3 and p28, is a pleiotropic cytokine with both pro-and anti-inflammatory properties. However, the precise role of IL-27 i...
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Article
Open AccessTRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity
Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase, which plays an essential role in both innate and adaptive immunity. However, the key molecular mechanisms that regulate SYK activity are poorly u...
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Article
Open AccessHigh stearic acid diet modulates gut microbiota and aggravates acute graft-versus-host disease