13 Result(s)
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Biochemistry, general
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Article
Open AccessThe long non-coding RNA keratin-7 antisense acts as a new tumor suppressor to inhibit tumorigenesis and enhance apoptosis in lung and breast cancers
Expression of the long non-coding RNA (lncRNA) keratin-7 antisense (KRT7-AS) is downregulated in various types of cancer; however, the impact of KRT7-AS deficiency on tumorigenesis and apoptosis is enigmatic. ...
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Reference Work Entry In depth
Extracellular Vesicle-Mediated CRISPR/Cas Delivery: Their Applications in Molecular Imaging and Precision Biomedicine
In this book chapter, we provide a comprehensive overview of the latest breakthroughs of delivery systems of CRISPR-Cas via extracellular vesicles (EVs) towards precise therapeutics and diagnosis. Typically, r...
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Living Reference Work Entry In depth
Extracellular Vesicle-Mediated CRISPR/Cas Delivery: Their Applications in Molecular Imaging and Precision Biomedicine
In this book chapter, we provide a comprehensive overview of the latest breakthroughs of delivery systems of CRISPR-Cas via extracellular vesicles (EVs) towards precise therapeutics and diagnosis. Typically, r...
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Article
Long Non-coding RNA TPT1-AS1 Suppresses APC Transcription in a STAT1-Dependent Manner to Increase the Stemness of Colorectal Cancer Stem Cells
Cancer stem cells (CSCs) are the major culprits leading to a new level of complexity and the consequential therapy resistance and disease recurrence in colorectal cancer (CRC). This study focuses on the effect...
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Article
Design and Antibacterial Mechanism of Peptides Derived from Sakacin P
Pseudomonas aeruginosa easily obtains multidrug resistance and forms biofilm. These properties bring more challenges to its control. Antimicrobial peptides (AMPs) can inhibit the formation of biofilms. However th...
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Article
The construction of a dual-functional strain that produces both polysaccharides and sulfotransferases
Heparosan is used as the starting polysaccharide sulfated using sulfotransferase to generate fully elaborate heparin, a widely used clinical drug. However, the preparation of heparosan and enzymes was consider...
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Article
Metabolomics integrated with transcriptomics: assessing the central metabolism of marine red yeast Sporobolomyces pararoseus under salinity stress
Salinity stress is one of the most serious environmental issues in agricultural regions worldwide. Excess salinity inhibits root growth of various crops, and results in reductions of yield. It is of crucial to...
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Article
Heparin stimulates biofilm formation of Escherichia coli strain Nissle 1917
Escherichia coli strain Nissle 1917 (EcN), a gut probiotic competing with pathogenic bacteria, has been used to attenuate various intestinal dysfunctions. Heparin is a sulfated glycosaminoglycan enriched in the h...
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Article
Open AccessFibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development
The reconstitution of the T-cell repertoire and quantity is a major challenge in the clinical management of HIV infection/AIDS, cancer, and aging-associated diseases. We previously showed that autologous bone ...
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Article
Apamin-Sensitive K+ Current Upregulation in Volume-Overload Heart Failure is Associated with the Decreased Interaction of CK2 with SK2
Recent studies have shown that the sensitivity of apamin-sensitive K+ current (I KAS, mediated by apamin-sensitive small conductance calcium-activated potassium channels subunits) to intra...
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Article
Bisoprolol reversed small conductance calcium-activated potassium channel (SK) remodeling in a volume-overload rat model
A recent study indicated that apamin-sensitive current (I KAS, mediated by apamin-sensitive small conductance calcium-activated potassium channels subunits) density significantly increased in hear...
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Article
Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy
Tumor microenvironment (TME) is important in tumor development and may be a target for anti-cancer therapy. The genesis of TME is a dynamic process that is regulated by intrinsic and extrinsic factors and coor...
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Article
An Improved Method of Gene Synthesis Based on DNA Works Software and Overlap Extension PCR
A bottleneck in recent gene synthesis technologies is the high cost of oligonucleotide synthesis and post-synthesis sequencing. In this article, a simple and rapid method for low-cost gene synthesis technology...
