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    Article

    ACE-Inhibitors in Hypertension: A Historical Perspective and Current Insights

    This review describes the discovery and development of ACE inhibitors as antihypertensive agents, compares their efficacy, tolerability, and safety to ARBs, and highlights the contemporary issues surrounding A...

    Stacey Cutrell, Ibrahim S. Alhomoud, Anurag Mehta in Current Hypertension Reports (2023)

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    Open Access

    Abnormal left ventricular subendocardial perfusion and diastolic function in women with obesity and heart failure and preserved ejection fraction

    – Coronary microvascular dysfunction (CMD) is common in patients with heart failure with preserved ejection fraction (HFpEF) and obesity. Stress cardiovascular magnetic resonance (CMR) has been proposed as a n...

    Roshanak Markley, Marco Giuseppe Del Buono in The International Journal of Cardiovascula… (2023)

  3. Article

    Open Access

    Rationale and design of interleukin-1 blockade in recently decompensated heart failure (REDHART2): a randomized, double blind, placebo controlled, single center, phase 2 study

    Heart failure (HF) is a global leading cause of mortality despite implementation of guideline directed therapy which warrants a need for novel treatment strategies. Proof-of-concept clinical trials of anakinra...

    Benjamin Van Tassell, Virginia Mihalick in Journal of Translational Medicine (2022)

  4. Article

    Open Access

    Interleukin-1 blockade in cardiac sarcoidosis: study design of the multimodality assessment of granulomas in cardiac sarcoidosis: Anakinra Randomized Trial (MAGiC-ART)

    Sarcoidosis is an inflammatory disease characterized by the formation of granulomas, which involve the heart in up to 25% of patients. Cardiac sarcoidosis can lead to life threatening arrhythmias and heart fai...

    Jordana Kron, Thomas Crawford, Virginia Mihalick in Journal of Translational Medicine (2021)

  5. Article

    Cardiovascular Complications of COVID-19: Pharmacotherapy Perspective

    Coronavirus disease of 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly the world over. The disease was declared “pandemic” by the World He...

    Azita Hajhossein Talasaz, Hessam Kakavand in Cardiovascular Drugs and Therapy (2021)