80 Result(s)
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Article
Glomerular Losartan (DuP 753)-Sensitive Angiotensin II Receptor Density Is Increased in Young Spontaneously Hypertensive Rats
ABSTRACT: There is increasing evidence that an activated intrarenal renin-angiotensin system (RAS) alters renal hemodynamics and fluid balance and that such events may lead to the development of hypertension. ...
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Congenital Hypogonadotropic Hypogonadism and Micropenis: Effect of Testosterone Treatment on Adult Penile Size. • 403
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Article
Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-β1 stimulation
We have shown previously that integrin-linked kinase (ILK) is upregulated in human HT-144 melanoma cells following TGF-β1 stimulation. Using mRNA from TGF-β1 stimulated HT-144 cells and reverse transcriptase p...
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Antiviral agent Cidofovir restores p53 function and enhances the radiosensitivity in HPV-associated cancers
High-risk human papillomaviruses (HPVs) have been associated to the development of cervical and some other human cancers. Most of them express E6 and E7 oncoproteins, able to bind to p53 and retinoblastoma (pR...
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Rapid tumor development and potent vascularization are independent events in carcinoma producing FGF-1 or FGF-2
FGF-1 and FGF-2 are pleiotropic growth factors for many cell types, operating through the activation of specific transmembrane FGF receptors (FGFRs). The role of these factors in tumor progression was investig...
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Antiviral agent Cidofovir decreases Epstein–Barr virus (EBV) oncoproteins and enhances the radiosensitivity in EBV-related malignancies
The Epstein–Barr virus (EBV) is involved in the carcinogenesis of several human cancers such as nasopharyngeal carcinoma (NPC) and Burkitt lymphoma (BL). Given the consistent role of EBV in transformation and ...
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Cerebral Venous Sinus Thrombosis in a Neonate with Homozygous Prothrombin G20210A Genotype
We describe a 7-day-old infant who presented with extensive cerebral venous sinus thrombosis (CVST) and was found to be homozygous for the prothrombin G20210A gene mutation. No other known risk factors for thr...
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Renovascular Hypertension: A Unique Cause of Unilateral Focal Segmental Glomerulosclerosis
A 48-year-old man presented with malignant hypertension and massive proteinuria. Renal angiography showed complete obstruction of the left renal artery and 99mTc-mercaptoacetylglycine (MAG3) renography showed a n...
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Article
Irradiation at 634 nm releases nitric oxide from human monocytes
Previous studies have shown that irradiation at 634 nm decreases the release of extracellular reactive oxygen species (ROS) without affecting viability in human monocytes. Here, we examined the effect of irrad...
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Leiomyosarcoma of the Abdominal Aorta: A Rare Cause of Renovascular Hypertension
We describe the case of a 44-year-old woman who presented with renovascular hypertension caused by primary leiomyosarcoma of the abdominal aorta that had metastasized into the renal arteries. Despite an extens...
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Article
To Resurface or Not to Resurface the Patella in Total Knee Arthroplasty
The management of the patellar articular surface at the time of primary total knee arthroplasty (TKA) is controversial. We used expected-value decision analysis to determine whether the patella should be resur...
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Modular Tantalum Augments for Acetabular Defects in Revision Hip Arthroplasty
Large acetabular defects can be reconstructed with various methods depending on size and location of the defect. We prospectively followed our first 37 patients in whom we reconstructed the acetabulum with a t...
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Open AccessOptimizing TILLING and Ecotilling techniques for potato (Solanum tuberosum L)
The TILLING and Ecotilling techniques for the discovery of nucleotide polymorphisms were applied to three potato (Solanum tuberosum) cultivars treated with gamma irradiation. The three mutant cultivars tested wer...
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Open AccessSTAT1-dependent expression of energy metabolic pathways links tumour growth and radioresistance to the Warburg effect
The Signal Transducer and Activator of Transcription 1 (STAT1) has traditionally been regarded as a transmitter of interferon signaling and a pro-apoptotic tumour suppressor. Recent data have identified new fu...
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Femoral Revision Hip Arthroplasty: A Comparison of Two Stem Designs
For various reasons the tapered, fluted, modular titanium (TFMT) stem has become our component of choice over cylindrical, nonmodular cobalt chrome (CNCC) components for THA revision. We therefore asked whethe...
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The John Charnley Award: Metal-on-Metal Hip Resurfacing versus Large-diameter Head Metal-on-Metal Total Hip Arthroplasty: A Randomized Clinical Trial
Resurfacing arthroplasty has become an attractive option for young patients who want to maintain a high activity level. One recent study reported modestly increased activity levels for patients with resurfacin...
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Article
Tranexamic Acid Reduces Allogenic Transfusion in Revision Hip Arthroplasty
Revision THA is associated with high blood loss and a high probability of blood transfusion in the perioperative period. In November 2003, government legislation established the Blood Utilization Program at ou...
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Article
Quality of Life Following Proximal Femoral Replacement Using a Modular System in Revision THA
Proximal femoral replacement using a segmental modular system is one option for revision THA in the presence of severe bone loss or periprosthetic fracture. While many papers report function in these patients,...
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Two-stage Total Hip Arthroplasty: How Often Does It Control Methicillin-resistant Infection?
Methicillin-resistant hip infections are increasingly common. Reports of the surgical management of these patients using two-stage THA show variable control of infection, but all reports used static spacers.
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Article
Durable Infection Control and Function With the PROSTALAC Spacer in Two-stage Revision for Infected Knee Arthroplasty
A two-stage revision total knee arthroplasty is recognized as the gold standard in the treatment of infection. However, traditional spacers limit function in the interval between the two stages and may cause i...
