6 Result(s)
within
Barbara A Weir
Life Sciences
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Article
Open AccessThe methyltransferase domain of DNMT1 is an essential domain in acute myeloid leukemia independent of DNMT3A mutation
Aberrant DNA methylation patterns are a prominent feature of cancer. Methylation of DNA is mediated by the DNA methyltransferase (DNMT) protein family, which regulates de novo (DNMT3A and DNMT3B) and maintenance ...
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Article
Characterizing genomic alterations in cancer by complementary functional associations
Complementary genomic features associated with pathway activation, gene dependency and drug sensitivity are uncovered using REVEALER.
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Article
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
A method called PRISM rapidly identifies drug candidates that are effective against specific cancer cell lines.
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Article
Absolute quantification of somatic DNA alterations in human cancer
Tumors vary in their ratio of normal to cancerous cells and in their genomic copy number. Carter et al. describe an analytic method for inferring the purity and ploidy of a tumor sample, enabling longitudinal stu...
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Article
Towards patient-based cancer therapeutics
Orienting cancer drug discovery to the patient requires relating the genetic features of tumors to acquired gene and pathway dependencies and identifying small-molecule therapeutics that target them.
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Article
Open AccessMajor copy proportion analysis of tumor samples using SNP arrays
Single nucleotide polymorphisms (SNPs) are the most common genetic variations in the human genome and are useful as genomic markers. Oligonucleotide SNP microarrays have been developed for high-throughput geno...
