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Open AccessPerioperative blood transfusion has distinct postsurgical oncologic impact on patients with different stage of hepatocellular carcinoma
The influence of perioperative blood transfusion (PBT) on postsurgical survival of patients with different stage of hepatocellular carcinoma (HCC) is not well clarified. This study aimed to evaluate the impact...
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Article
Open AccessHornerin promotes tumor progression and is associated with poor prognosis in hepatocellular carcinoma
The function of hornerin (HRNR), a member of the S100 protein family, is poorly clarified in the development of human tumors. The role of HRNR in hepatocellular carcinoma (HCC) progression is investigated in t...
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Article
Open AccessLow expression of c-Myc protein predicts poor outcomes in patients with hepatocellular carcinoma after resection
Embryonic Liver Fodrin (ELF) is an adaptor protein of transforming growth factor (TGF-β) signaling cascade. Disruption of ELF results in mislocalization of Smad3 and Smad4, leading to compromised TGF-β signali...
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Article
Open AccessA novel and accurate predictor of survival for patients with hepatocellular carcinoma after surgical resection: the neutrophil to lymphocyte ratio (NLR) combined with the aspartate aminotransferase/platelet count ratio index (APRI)
The occurrence and development of hepatocellular carcinoma (HCC) depends largely on such non-tumor factors as inflammatory condition, immune state, viral infection and liver fibrosis. Various inflammation-base...
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Article
Open AccessThe prognostic value of combined TGF-β1 and ELF in hepatocellular carcinoma
Tumor suppression of Transforming Growth Factor (TGF-β) signaling pathway requires an adaptor protein, Embryonic Liver Fodrin (ELF). Disruption of ELF expression resulted in miscolocalization of Smad3 and Smad...
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Article
Open AccessElevated preoperative peripheral blood monocyte count predicts poor prognosis for hepatocellular carcinoma after curative resection
Peripheral blood monocyte count is an easily assessable parameter of systemic inflammatory response. The aim of this study was to determine whether monocyte count was prognostic in hepatocellular carcinoma (HC...
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Article
Open AccessOverexpression of GOLPH3 is associated with poor prognosis and clinical progression in pancreatic ductal adenocarcinoma
Golgi phosphoprotein 3 (GOLPH3) has been identified as an oncoprotein in various human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. We examined GOLPH3 expression levels and...
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Article
Open AccessPrognostic significance of neutrophil-lymphocyte ratio in hepatocellular carcinoma: a meta-analysis
Neutrophil-lymphocyte ratio (NLR) has recently been reported as a predictor of Hepatocellular carcinoma (HCC). However, its prognostic value in HCC still remains controversial. In this study, we aimed to evalu...
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Article
Open AccessPrognostic significance of glypican-3 in hepatocellular carcinoma: a meta-analysis
Glypican-3(GPC3) has been implicated in tumor development and progression for several years. However, the prognostic significance of GPC3 expression in patients with hepatocellular carcinoma (HCC) is controver...